Best Central alpha-2 Adrenergic Agonist for glaucoma
Top-rated pick: Clonidine Hydrochloride — pharmaranks score 72/100, the highest of the 8 Central alpha-2 Adrenergic Agonist drugs used for glaucoma, ranked by our independent FDA recall-safety score. Compare them with all treatments for glaucoma or the full Central alpha-2 Adrenergic Agonist class. Not medical advice — always consult a professional.
Quick answer: Of the 8 central alpha-2 adrenergic agonist drugs we rate for glaucoma, all are available as lower-cost generics, and most are patch. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for glaucoma; the right choice depends on your situation, so confirm it with your prescriber.
How central alpha-2 adrenergic agonist work
These drugs activate alpha-2 receptors in the brainstem, which tells the nervous system to send out less norepinephrine and reduce sympathetic (fight-or-flight) signaling to the body. With less of this stimulation, blood vessels relax and heart rate slows, lowering blood pressure.
Other drug classes for glaucoma
Top central alpha-2 adrenergic agonist for glaucoma: 1. Clonidine Hydrochloride · 2. Onyda XR · 3. Javadin
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 72/100 | Prescription | Injectable | Generic | $1 | View → | |
| 2 | 72/100 | Prescription | Suspension | Generic | $1 | View → | |
| 3 | 70/100 | Prescription | Solution | Generic | $1 | View → | |
| 4 | 68/100 | Prescription | Injectable | Generic | $1 | View → | |
| 5 | Not yet rated | Prescription | Patch | Generic | $1 | View → | |
| 6 | Not yet rated | Prescription | Patch | Generic | $1 | View → | |
| 7 | Not yet rated | Prescription | Patch | Generic | $1 | View → | |
| 8 | Not yet rated | Prescription | Tablet | Generic | $1 | View → |
Full ranking · 8 drugs
clonidine hydrochloride
PrescriptionFDA-sourced
Clonidine Hydrochloride is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in classonyda xr
PrescriptionFDA-sourced
Onyda XR (Clonidine Hydrochloride) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in classjavadin
PrescriptionFDA-sourced
Javadin (Clonidine Hydrochloride) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in classduraclon
Boxed warningPrescriptionFDA-sourced
Duraclon (Clonidine Hydrochloride) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in class
catapres-tts-1
PrescriptionFDA-sourced
Catapres-Tts-1 (Clonidine) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in classcatapres-tts-2
PrescriptionFDA-sourced
Catapres-Tts-2 (Clonidine) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in classcatapres-tts-3
PrescriptionFDA-sourced
Catapres-Tts-3 (Clonidine) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in classnexiclon xr
PrescriptionFDA-sourced
Nexiclon XR (Clonidine) is a central alpha-2 adrenergic agonist used to treat Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea, Tourette Syndrome.
Pharmacy pays
From ~$0.75/30· 8 forms Save up to 5% in classFrequently asked
- What is the best central alpha-2 adrenergic agonist for glaucoma?
- By our independent recall-safety rating — not an efficacy measure — clonidine hydrochloride ranks highest among Central alpha-2 Adrenergic Agonist drugs used for glaucoma. Always consult a professional.
- Which central alpha-2 adrenergic agonist drugs treat glaucoma?
- pharmaranks lists 8 Central alpha-2 Adrenergic Agonist products used for glaucoma, per NIH RxClass drug-classification data — each independently rated and ranked above.
- How are these ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.