Which atypical antipsychotic drugs treat major depressive disorder?

pharmaranks lists 7 Atypical Antipsychotic products indicated for major depressive disorder, per FDA drug-label data — each independently rated and ranked above.

How are these ranked?

By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.

Best Atypical Antipsychotic for major depressive disorder

7 Atypical Antipsychotic drugs indicated for major depressive disorder, ranked by our independent rating. The current highest-rated is fluoxetine hydrochloride. Compare them with all treatments for major depressive disorder or the full Atypical Antipsychotic class. Not medical advice — always consult a professional.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Top atypical antipsychotic for major depressive disorder: 1. Fluoxetine Hydrochloride · 2. Lurasidone Hydrochloride · 3. Seroquel

Best-rated Atypical Antipsychotic for major depressive disorder, ranked by pharmaranks score
#	Drug	Rating	Type	Typical price
1	Fluoxetine Hydrochloride	Not yet rated	Prescription	$0	View →
2	Lurasidone Hydrochloride	Not yet rated	Prescription	$9	View →
3	Seroquel	Not yet rated

Full ranking · 7 drugs

fluoxetine hydrochloride

PrescriptionFDA-sourced

New

Fluoxetine capsules, USP are a selective serotonin reuptake inhibitor for oral administration.

atypical antipsychoticserotonin reuptake inhibitorbulimia

Typical price

From ~$0.03· 8 forms

View details →

Frequently asked

What is the best atypical antipsychotic for major depressive disorder?: By our independent rating, fluoxetine hydrochloride currently ranks highest among Atypical Antipsychotic drugs used for major depressive disorder. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.
Which atypical antipsychotic drugs treat major depressive disorder?: pharmaranks lists 7 Atypical Antipsychotic products indicated for major depressive disorder, per FDA drug-label data — each independently rated and ranked above.
How are these ranked?: By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.

Best Atypical Antipsychotic for major depressive disorder

fluoxetine hydrochloride

Frequently asked

lurasidone hydrochloride

seroquel

quetiapine fumarate

latuda

seroquel xr

olanzapine and fluoxetine hydrochloride