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Best supplements for gut health

The 7 supplements people most often use for gut health. Supplements aren't FDA recall-rated like drugs and the evidence varies, so we list them as options — not a fabricated ranking — and tell you what to look for. Not medical advice.

By the pharmaranks editorial teamReviewed against NIH & NCCIH sourcesHow we research
  1. 1

    Colostrum

    Bovine Colostrum

    Early-milk antibodies taken for immune and gut support.

    Benefits, dosage & safety →
  2. 2

    Digestive Enzymes

    Amylase, Protease & Lipase

    An enzyme blend taken with meals to support digestion and reduce bloating.

    Benefits, dosage & safety →
  3. 3

    Oregano Oil

    Oil of Oregano

    A concentrated herbal oil taken for immune and gut support.

    Benefits, dosage & safety →
  4. 4

    Combines probiotics with prebiotic fiber to support the gut microbiome.

    Benefits, dosage & safety →
  5. 5

    Probiotics

    Lactobacillus & Bifidobacterium

    Live beneficial bacteria supporting digestive and immune health.

    Benefits, dosage & safety →
  6. 6

    Slippery Elm

    Ulmus Rubra

    An herbal mucilage traditionally used to soothe the digestive tract and throat.

    Benefits, dosage & safety →
  7. 7

    Turkey Tail

    Trametes Versicolor

    A medicinal mushroom studied for immune and gut support.

    Benefits, dosage & safety →

What to look for in a gut health supplement

With supplements, quality varies more by brand than by ingredient. Favor brands with independent third-party testing and certification — NSF, NSF Certified for Sport, USP Verified, Informed Sport — over unverified labels.

FAQ

What is the best supplement for gut health?
There's rarely a single best — the options below are the supplements most commonly used for gut health. Evidence strength varies by ingredient and by person. Favor a form from a brand with independent third-party testing (NSF, USP Verified, Informed Sport), and check with a healthcare professional before starting.
Are gut health supplements FDA-approved?
No. The FDA regulates supplements as food, not drugs — they aren't approved for safety and effectiveness before sale. That makes third-party testing and certification the most useful quality signal, which is what we point to.
Do supplements replace medication for gut health?
No. Supplements are not a substitute for prescribed treatment. This page is general reference, not medical advice — talk to a licensed professional, especially if you take medication.

This page is general reference and not medical advice. Supplement evidence varies and is often limited; statements here have not been evaluated by the FDA. Consult a licensed healthcare professional before starting any supplement.