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vimovo

Vimovo is a combination medicine containing Esomeprazole Magnesium and Naproxen.

Esomeprazole Magnesium and Naproxen · by Horizon

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Active ingredient
Esomeprazole Magnesium and Naproxen
Form
Tablet, delayed release
Strength
Esomeprazole Magnesium EQ 20MG Base; Naproxen 375MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Esomeprazole Magnesium EQ 20MG Base; Naproxen 500MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons**
Type
Prescription (Rx)
Brand or generic
Brand-name
Manufacturer
Horizon
Half-life
about 12 to 17 hours (how long it stays in your system)
FDA application
NDA022511
Availability
Discontinued (per FDA)

How long does Esomeprazole Magnesium and Naproxen stay in your body?

The elimination half-life of esomeprazole magnesium and naproxen is about 12 to 17 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is naproxen's elimination (terminal) half-life in healthy adults; its metabolites have shorter half-lives, so there is no longer-acting active metabolite to account for. The half-life is prolonged in severe renal impairment, and above 500 mg/day the drug shows nonlinear (dose-dependent) kinetics because plasma protein binding becomes saturated.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: NAPROXEN tablet, delayed release — DailyMed (FDA label).

Dosage forms

Tablet, delayed release

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

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Frequently asked questions

Is there a coupon or discount for Vimovo?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Vimovo. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Vimovo?
Vimovo is marketed by Horizon. You can see Horizon's full profile, rating, and other products on pharmaranks.
Is Vimovo a brand-name or generic drug?
Vimovo is a brand-name product with the active ingredient Esomeprazole Magnesium and Naproxen.
Is Vimovo available over the counter?
No. Vimovo is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Vimovo come in?
Vimovo is currently marketed as tablet, delayed release, per the FDA's National Drug Code Directory.
Is Vimovo FDA-registered?
Vimovo is on record with the U.S. FDA under application number NDA022511. You can verify this on its official FDA label.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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