vectical
Vectical (Calcitriol) is a vitamin d3 analog used to treat Hyperparathyroidism, Hypocalcemia, Psoriasis, Rickets.
Calcitriol · by Galderma Labs LP
Available as a generic: Calcitriol
Key facts
- Active ingredient
- Calcitriol
- Drug class
- Vitamin D3 Analog
- Form
- Topical
- Strength
- Calcitriol 3MCG/GM
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- May treat
- hyperparathyroidism, hypocalcemia, psoriasis
- Manufacturer
- Galderma Labs LP
- What the pharmacy pays
- ~$5.08 for 30 — not your price
- FDA application
- NDA022087
What is Vectical?
From the FDA label:Calcitriol Ointment, 3 mcg/g is a vitamin D analog intended for topical application to the skin. The chemical name of the active ingredient is (5Z,7E)-9, 10-secocholesta-5,7,10(19)-triene-1α, 3β,25-triol. The structural formula is: Calcitriol is a white or almost white crystalline solid. It is practically insoluble in water, soluble in alcohol and in fatty oils. The molecular formula is C 27 H 44 O 3 , and the molecular weight is 416.64. Calcitriol Ointment is a translucent ointment containing 3 mcg/g (0.0003% w/w) of calcitriol, packaged in aluminum tubes with screw caps. Other components of the ointment are mineral oil, dl-α-tocopherol, and white petrolatum. chem-stuct
How to use
Apply Calcitriol Ointment to affected areas twice daily, morning and evening. Adults: the maximum weekly dose should not exceed 200 grams. Pediatrics: 2 to 6 years of age: the maximum weekly dose should not exceed 100 grams. 7 years of age and older: the maximum weekly dose should not exceed 200 grams Calcitriol Ointment should not be applied to the eyes, lips, or facial skin. Calcitriol Ointment is for topical use only. Calcitriol Ointment is not for oral, ophthalmic or intravaginal use. Apply Calcitriol Ointment to affected areas of the body twice daily ( 2 ). Adults: The maximum weekly dose should not exceed 200 grams. ( 2 ) Pediatrics: 2 to 6 years of age: the maximum weekly dose should not exceed 100 grams. ( 2 ) 7 years of age and older: the maximum weekly dose should not exceed 200 grams. ( 2 ) For topical use only. ( 2 ) Not for oral, ophthalmic, or intravaginal use. ( 2 )
Side effects
Most common adverse reactions (incidence > 3%) are hypercalcemia, hypercalciuria, and skin discomfort. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Padagis at 1-866-634-9120 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch . 6.1 Clinical Trials Experience Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice. Calcitriol Ointment was studied in two vehicle-controlled trials and one open label trial, resulting in 743 subjects exposed to Calcitriol Ointment. Table 1 describes adverse events in subjects treated with Calcitriol Ointment twice daily for 8 weeks. The population included subjects ages 13 to 87 years, males (284) and females (135), Caucasians (372) and non-Caucasians (47); with mild (105) to moderate (313) chronic plaque psoriasis. Table 1. Selected Adverse Events Occurring in at least 1% of Subjects in the Two Pooled Vehicle-Controlled Trials Calcitriol Ointment (n=419) Vehicle Ointment (n=420) Discomfort Skin 3% 2% Pruritus 1% 1% Among subjects having laboratory monitoring, hypercalcemia was observed in 24% (18/74) of subjects exposed to active drug and in 16% (13/79) of subjects exposed to vehicle, however the elevation were less than 10% above the…
Warnings
Important safety information
Effects on Calcium metabolism: Risk of hypercalcemia. If aberrations in parameters of calcium metabolism are noted discontinue Calcitriol Ointment until these normalize. Increased absorption may occur with occlusive use. ( 5.1 ) Calcitriol Ointment should be used with caution in patients receiving medications known to increase the serum calcium level, such as thiazide diuretics, and in patients receiving calcium supplements or high doses of vitamin D. ( 5.1 ) 5.1 Effects on Calcium Metabolism In controlled clinical trials hypercalcemia was observed in subjects exposed to Calcitriol Ointment. If aberrations in parameters of calcium metabolism occur, treatment should be discontinued until these parameters have normalized. The effects of Calcitriol Ointment on calcium metabolism following treatment durations greater than 52 weeks have not been evaluated. Increased absorption may occur with occlusive use. Calcitriol Ointment should be used with caution in patients receiving medications know to increase the serum calcium level, such as thiazide diuretics, and in patients receiving calcium supplements or high doses of vitamin D.
Who should not take Vectical
None None ( 4 )
Overdose — what happens if you take too much
Topically applied calcitriol can be absorbed in sufficient amounts to produce systemic effects [ see WARNINGS AND PRECAUTIONS ( 5.1 )]
U.S. Poison Control: call or text 1-800-222-1222 (free, 24/7). In an emergency call 911. From the FDA label; not medical advice.
Drug class
May treat (source: NIH RxClass)
See how Vectical ranks — best-rated vitamin d3 analog for:
Dosage forms
Topical
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
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Frequently asked questions
- What does Vectical treat?
- Vectical (Calcitriol) may be used to treat hyperparathyroidism, hypocalcemia, psoriasis, rickets, vitamin e deficiency, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- How much does Vectical cost?
- Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $5.08 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
- Is there a coupon or discount for Vectical?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Vectical. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Vectical?
- Vectical is marketed by Galderma Labs LP. You can see Galderma Labs LP's full profile, rating, and other products on pharmaranks.
- Is Vectical a brand-name or generic drug?
- Vectical is a brand-name product with the active ingredient Calcitriol. Lower-cost generic equivalents containing Calcitriol are available — ask your pharmacist.
- Is Vectical available over the counter?
- No. Vectical is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Vectical come in?
- Vectical is currently marketed as topical, per the FDA's National Drug Code Directory.
- What class of drug is Vectical?
- Vectical is classified as vitamin d3 analog, per the FDA's Established Pharmacologic Class.
- Is Vectical FDA-registered?
- Vectical is on record with the U.S. FDA under application number NDA022087. You can verify this on its official FDA label.
- Is Vectical safe?
- There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Vectical. Review its FDA-label side effects and warnings below, and always consult a licensed professional.
- What are the side effects of Vectical?
- Vectical's side effects are taken directly from its FDA label. From the label: Most common adverse reactions (incidence > 3%) are hypercalcemia, hypercalciuria, and skin discomfort. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Padagis at 1-866-634-9120 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch .… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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