tissueblue
Tissueblue (Brilliant Blue G) is a medication supplied as an injection, solution.
Brilliant Blue G · by Dutch Ophthalmic
Key facts
- Active ingredient
- Brilliant Blue G
- Form
- Injectable
- Strength
- Brilliant Blue G 0.025%
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- Manufacturer
- Dutch Ophthalmic
- FDA application
- NDA209569
What is Tissueblue?
From the FDA label:TissueBlue (Brilliant Blue G Ophthalmic Solution) 0.025% is a sterile solution of BBG (a dye) for intraocular ophthalmic use. Each mL of TissueBlue 0.025% contains BBG 0.25 mg, polyethylene glycol and buffered sodium chloride solution (sodium chloride, dibasic sodium phosphate, monobasic sodium phospage, water for injection). Phosphoric acid and/or sodium hydroxide may also be used for pH adjustment. The pH range of TissueBlue 0.025% Solution is between 7.3 and 7.6. The drug substance BBG has the chemical name Brilliant Blue G, a molecular weight of 854.02 and has the following chemical structure: Molecular formula: C 47 H 48 N 3 NaO 7 S 2 BBG.jpg
How to use
Dosage & Administration TissueBlue 0.025% is carefully injected into the Balanced Salt Solution (BSS)-filled vitreous cavity using a blunt cannula attached to the pre-filled syringe, without allowing the cannula to contact the retina or allowing TissueBlue to get under the retina. Sufficient staining is expected within a few seconds. Following staining, all excess dye should be removed from the vitreous cavity. Inject TissueBlue 0.025% directly in a Balanced Salt Solution (BSS)-filled vitreous cavity. Excess TissueBlue should be removed from the vitreous cavity.
Side effects
Adverse reactions that have been reported in procedures that included the use of Brilliant Blue G Ophthalmic Solution have often been associated with the surgical procedure. These complications include retinal (retinal break, tear, hemorrhage, and detachment) and cataracts. Adverse reactions that have been reported in procedures that included the use of TissueBlue 0.025% have often been associated with the surgical procedure. The complications include retinal (retinal break, tear, hemorrhage, and detachment and cataracts. To report SUSPECTED ADVERSE REACTIONS, contact Dutch Ophthalmic, USA at 1-800-75-DUTCH or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch
Warnings
Important safety information
Excessive Staining Excess TissueBlue 0.025% should be removed from the eye immediately after staining. Use of the Syringe Make sure the plunger moves smoothly before injecting the solution. Do not use the product if the plunger does not move smoothly to prime the cannula. Excessive staining: Excess TissueBlue 0.025% should be removed from the eye immediately after staining. Use of the syringe: Make sure the plunger moves smoothly before injecting the solution.
Who should not take Tissueblue
None None
Dosage forms
Injectable
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
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Frequently asked questions
- Is there a coupon or discount for Tissueblue?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Tissueblue. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Tissueblue?
- Tissueblue is marketed by Dutch Ophthalmic. You can see Dutch Ophthalmic's full profile, rating, and other products on pharmaranks.
- Is Tissueblue a brand-name or generic drug?
- Tissueblue is a brand-name product with the active ingredient Brilliant Blue G.
- Is Tissueblue available over the counter?
- No. Tissueblue is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Tissueblue come in?
- Tissueblue is currently marketed as injectable, per the FDA's National Drug Code Directory.
- Is Tissueblue FDA-registered?
- Tissueblue is on record with the U.S. FDA under application number NDA209569. You can verify this on its official FDA label.
- Is Tissueblue safe?
- There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Tissueblue. Review its FDA-label side effects and warnings below, and always consult a licensed professional.
- What are the side effects of Tissueblue?
- Tissueblue's side effects are taken directly from its FDA label. From the label: Adverse reactions that have been reported in procedures that included the use of Brilliant Blue G Ophthalmic Solution have often been associated with the surgical procedure. These complications include retinal (retinal break, tear, hemorrhage, and detachment) and cataracts.… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
What people report to the FDA about BRILLIANT BLUE G
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 7 reports naming BRILLIANT BLUE G — the active ingredient in Tissueblue, and the FDA flagged 100% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- toxic anterior segment syndrome2 reports
- visual impairment2 reports
- drug hypersensitivity1 reports
- eye injury1 reports
- hemianopia1 reports
- impaired quality of life1 reports
- iris adhesions1 reports
- neoplasm malignant1 reports
Read these as a signal, not a rate. A report does not mean BRILLIANT BLUE G caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.
Source: openFDA drug/event (FAERS), retrieved September 25, 2026.
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