teczem

How long does Diltiazem Malate and Enalapril Maleate stay in your body?

The elimination half-life of diltiazem malate and enalapril maleate is about 3 to 4.5 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the plasma elimination half-life of diltiazem itself after single or repeated dosing, in adults with normal organ function. The label elsewhere quotes a slightly wider 2-to-5-hour range for the drug. Three things change that number. (1) Extended-release forms: the label reports an apparent elimination half-life of 5 to 8 hours for the extended-release capsule. That is the slow release of the formulation, not a change in how fast the body clears the drug. (2) An active metabolite: desacetyldiltiazem circulates at 10% to 20% of parent levels and is 25% to 50% as potent a coronary vasodilator as diltiazem, so some activity outlasts the parent drug's numbers. The label does not state a half-life for desacetyldiltiazem, so none is given here. The label does note that metabolites are eliminated more slowly than the parent, with a total-radioactivity half-life of about 20 hours. (3) Dose: kinetics are not linear, and the label says half-life is slightly increased at higher doses. By population, the label says liver disease matters and kidney disease does not: in cirrhosis, half-life was increased and bioavailability rose 69%; in nine patients with severely impaired renal function, the pharmacokinetic profile did not differ from normal. The Geriatric Use section states nothing about half-life in older adults. Diltiazem is not a prodrug. These figures describe how long the drug stays in plasma; they are not a drug-test detection window (metabolites are detectable far longer) and are not dosing guidance.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: DailyMed - DILTIAZEM HYDROCHLORIDE capsule, extended release (Clinical Pharmacology - Pharmacokinetics and Metabolism).

Frequently asked questions

Is there a coupon or discount for Teczem?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Teczem. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Teczem?

Teczem is marketed by Biovail. You can see Biovail's full profile, rating, and other products on pharmaranks.

Is Teczem a brand-name or generic drug?

Teczem is a brand-name product with the active ingredient Diltiazem Malate and Enalapril Maleate.

Is Teczem available over the counter?

No. Teczem is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Teczem come in?

Teczem is currently marketed as tablet, extended release, per the FDA's National Drug Code Directory.

Is Teczem FDA-registered?

Teczem is on record with the U.S. FDA under application number NDA020507. You can verify this on its official FDA label.