synophylate

How long does Theophylline Sodium Glycinate stay in your body?

The elimination half-life of theophylline sodium glycinate is about 8.7 hours on average (range roughly 6 to 13 hours) in otherwise healthy non-smoking adults 16-60 years — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the elimination half-life; the label's Table I reports it directly and theophylline follows one-compartment-like kinetics with no clinically relevant longer-lasting active metabolite in adults and it is not a prodrug. The half-life is highly variable and rises markedly in several named populations: elderly (>60 years, normal cardiac/liver/renal function) about 9.8 h (range 1.6-18); liver disease prolongs it substantially - cirrhosis about 32 h (10-56), acute hepatitis about 19 h, cholestasis about 14 h; also longer in acute pulmonary edema (~19 h), sepsis with multi-organ failure (~19 h), and 3rd-trimester pregnancy (~13 h). Because theophylline is cleared by hepatic metabolism, the label ties prolongation to liver dysfunction and age rather than to kidney impairment (renal impairment is not listed as prolonging half-life in adults). The kinetics are non-linear, so half-life increases further at serum concentrations above ~20 mcg/mL. Half-life is shorter in smokers, children, and hyperthyroidism.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: Theophylline (Anhydrous) Extended-Release Tablets - DailyMed label, Clinical Pharmacology (Table I).

Frequently asked questions

What does Synophylate treat?

Synophylate (Theophylline Sodium Glycinate) may be used to treat apnea, asthma, bradycardia, bronchial spasm, bronchitis, pulmonary emphysema, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

Is there a coupon or discount for Synophylate?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Synophylate. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Synophylate?

Synophylate is marketed by Cent Pharms. You can see Cent Pharms's full profile, rating, and other products on pharmaranks.

Is Synophylate a brand-name or generic drug?

Synophylate is a brand-name product with the active ingredient Theophylline Sodium Glycinate.

Is Synophylate available over the counter?

No. Synophylate is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Synophylate come in?

Synophylate is currently marketed as elixir, per the FDA's National Drug Code Directory.

Is Synophylate FDA-registered?

Synophylate is on record with the U.S. FDA under application number NDA006333. You can verify this on its official FDA label.