supprelin
Pharmaranks rates Supprelin 3.6/5 for recall safety — an independent score from its FDA recall history and its manufacturer's record. Supprelin (Histrelin Acetate) is a medication used to treat Precocious Puberty.
Histrelin Acetate · by Shire
Based on 1 source · Recall-safety score from FDA recall history — this product's own recalls and its manufacturer's record. Not an efficacy or quality rating. methodology →
Key facts
- Active ingredient
- Histrelin Acetate
- Form
- Injectable
- Strength
- Histrelin Acetate EQ 0.2MG BASE/ML · Histrelin Acetate EQ 0.5MG BASE/ML · Histrelin Acetate EQ 1MG BASE/ML
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- May treat
- precocious puberty
- Manufacturer
- Shire
- FDA application
- NDA019836
- Availability
- Discontinued (per FDA)
May treat (source: NIH RxClass)
Dosage forms
Injectable
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
A same-class option may cost less. See alternatives →
Frequently asked questions
- What does Supprelin treat?
- Supprelin (Histrelin Acetate) may be used to treat precocious puberty, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- How is Supprelin rated?
- pharmaranks gives Supprelin a composite score of 3.6 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.
- Is there a coupon or discount for Supprelin?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Supprelin. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Supprelin?
- Supprelin is marketed by Shire. You can see Shire's full profile, rating, and other products on pharmaranks.
- Is Supprelin a brand-name or generic drug?
- Supprelin is a brand-name product with the active ingredient Histrelin Acetate.
- Is Supprelin available over the counter?
- No. Supprelin is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Supprelin come in?
- Supprelin is currently marketed as injectable, per the FDA's National Drug Code Directory.
- Is Supprelin FDA-registered?
- Supprelin is on record with the U.S. FDA under application number NDA019836. You can verify this on its official FDA label.
- Has Supprelin been recalled by the FDA?
- Supprelin has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.
- Is Supprelin safe?
- There's no single safe-or-not verdict. pharmaranks gives Supprelin a recall-safety score of 72/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.
Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
What people report to the FDA about HISTRELIN ACETATE
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 19 reports naming HISTRELIN ACETATE — the active ingredient in Supprelin, and the FDA flagged 89% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- infective pulmonary exacerbation of cystic fibrosis3 reports
- pseudomonas infection3 reports
- confusional state2 reports
- fall2 reports
- general physical health deterioration2 reports
- nausea2 reports
- transient global amnesia2 reports
- anaemia1 reports
Read these as a signal, not a rate. A report does not mean HISTRELIN ACETATE caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.
Source: openFDA drug/event (FAERS), retrieved September 25, 2026.
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supprelin
72/100