Key facts
- Active ingredient
- Sulfamethoxazole
- Form
- Tablet
- Strength
- Sulfamethoxazole 500MG
- Type
- Prescription (Rx)
- Brand or generic
- Generic
- May treat
- chlamydiaceae infections, enterobacteriaceae infections, nocardia infections
- Manufacturer
- Barr
- Half-life
- about 10 hours (how long it stays in your system)
- FDA application
- ANDA087189
- Availability
- Discontinued (per FDA)
How long does Sulfamethoxazole stay in your body?
The elimination half-life of sulfamethoxazole is about 10 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. The FDA label states the mean serum half-life of sulfamethoxazole is 10 hours (co-formulated with trimethoprim, whose half-life is 8 to 10 hours). Half-life is prolonged in patients with severely impaired renal function, requiring dosage adjustment; the elderly, who often have reduced kidney function, may also clear it more slowly. Sulfamethoxazole is not a prodrug; it is partly metabolized to an inactive N-acetylated metabolite that does not outlast the parent. Half-life is not the same as a drug-test detection window — the drug can remain detectable longer than a single half-life implies.
This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: DailyMed - Sulfamethoxazole and Trimethoprim Tablet (FDA label).
May treat (source: NIH RxClass)
- chlamydiaceae infections
- enterobacteriaceae infections
- nocardia infections
- otitis media
- pneumocystis pneumonia
- toxoplasmosis
Dosage forms
Tablet
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
A same-class option may cost less. See alternatives →
Frequently asked questions
- What does Sulfamethoxazole treat?
- Sulfamethoxazole (Sulfamethoxazole) may be used to treat chlamydiaceae infections, enterobacteriaceae infections, nocardia infections, otitis media, pneumocystis pneumonia, toxoplasmosis, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- Is there a coupon or discount for Sulfamethoxazole?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Sulfamethoxazole. To pay less, Sulfamethoxazole is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Sulfamethoxazole?
- Sulfamethoxazole is marketed by Barr. You can see Barr's full profile, rating, and other products on pharmaranks.
- Is Sulfamethoxazole a brand-name or generic drug?
- Sulfamethoxazole is a generic medication; its active ingredient is Sulfamethoxazole. Generics contain the same active ingredient as the brand-name original and are usually lower cost.
- Is Sulfamethoxazole available over the counter?
- No. Sulfamethoxazole is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Sulfamethoxazole come in?
- Sulfamethoxazole is currently marketed as tablet, per the FDA's National Drug Code Directory.
- Is Sulfamethoxazole FDA-registered?
- Sulfamethoxazole is on record with the U.S. FDA under application number ANDA087189. You can verify this on its official FDA label.
Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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