sodium phosphates
Sodium Phosphates is a combination medicine containing Sodium Phosphate, Dibasic, Heptahydrate, Sodium Phosphate, Monobasic, and Monohydrate.
Sodium Phosphate, Dibasic, Heptahydrate and Sodium Phosphate, Monobasic, Monohydrate · by Am Regent
Generic of Sodium Phosphates in Plastic Container
Key facts
- Active ingredient
- Sodium Phosphate, Dibasic, Heptahydrate and Sodium Phosphate, Monobasic, Monohydrate
- Form
- Injectable
- Strength
- Sodium PHOSPHATE, DIBASIC, Heptahydrate 1.34GM/5ML; Sodium PHOSPHATE, MONOBASIC, Monohydrate 1.38GM/5ML (268MG/ML · Sodium PHOSPHATE, DIBASIC, Heptahydrate 13.4GM/50ML; Sodium PHOSPHATE, MONOBASIC, Monohydrate 13.8GM/50ML (268MG/ML · Sodium PHOSPHATE, DIBASIC, Heptahydrate 4.02GM/15ML; Sodium PHOSPHATE, MONOBASIC, Monohydrate 4.14GM/15ML (268MG/ML
- Type
- Prescription (Rx)
- Brand or generic
- Generic
- Manufacturer
- Am Regent
- FDA application
- ANDA218314
What is Sodium Phosphates?
From the FDA label:Sodium Phosphates Injection, USP, 3 mM P/mL (millimoles/mL), is a sterile, nonpyrogenic, concentrated solution containing a mixture of monobasic sodium phosphate and dibasic sodium phosphate in water for injection. The solution is administered after dilution by the intravenous route as an electrolyte replenisher. It must not be administered undiluted. Each mL contains 276 mg of monobasic sodium phosphate, monohydrate and 142 mg of dibasic sodium phosphate, anhydrous (equivalent to 268 mg of dibasic sodium phosphate, heptahydrate). One mM of phosphorus weighs 31 mg, and the product provides 93 mg (approximately 3 mM) of phosphorus/mL plus 92 mg (4 mEq) of sodium/mL. Note: 1 mM P = 1 mM PO 4 . It contains no bacteriostat, antimicrobial agent or added buffer. The pH is 5.5 (5.0 to 6.0). The osmolar concentration is 7 mOsmol/mL (calc). The solution is intended as an alternative to potassium phosphate to provide phosphorus for addition to large volume infusion fluids for intravenous use. It is provided as a 5 mL, 15 mL and 50 mL partial fill single-dose vial; when lesser amounts are required, the unused portion should be discarded with the entire unit. Monobasic Sodium Phosphate, USP (monohydrate) is chemically designated NaH 2 PO 4 • H 2 O, white, odorless crystals or granules freely soluble in water. Dibasic Sodium Phosphate, USP (anhydrous) is chemically designated Na 2 HPO 4 ,…
How to use
Sodium Phosphates Injection, USP, 3 mM P/mL is administered intravenously only after dilution and thorough mixing in a larger volume of fluid . The dose and rate of administration are dependent upon the individual needs of the patient. Serum sodium, phosphorus and calcium levels should be monitored as a guide to dosage. Using aseptic technique, all or part of the contents of one or more vials may be added to other intravenous fluids to provide any desired number of millimoles (mM) of phosphorus. In patients on total parenteral nutrition, approximately 12 to 15 mM of phosphorus (equivalent to 372 to 465 mg elemental phosphorus) per liter bottle of TPN solution containing 250 g dextrose is usually adequate to maintain normal serum phosphorus, though larger amounts may be required in hypermetabolic states. The amount of sodium and phosphorus which accompanies the addition of sodium phosphate also should be kept in mind, and if necessary, serum sodium levels should be monitored. The suggested dose of phosphorus for infants receiving TPN is 1.5 to 2 mM P/kg/day. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.
Side effects
Adverse reactions involve the possibility of phosphorus intoxication. Phosphorus intoxication results in a reduction of serum calcium and the symptoms are those of hypocalcemic tetany. See WARNINGS . To report SUSPECTED ADVERSE REACTIONS, contact American Regent, Inc. at 1-800-734-9236 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Warnings
Important safety information
Sodium Phosphates Injection, USP, 3 mM P/mL must be diluted and thoroughly mixed before use. To avoid phosphorus intoxication, infuse solutions containing sodium phosphate slowly. Infusing high concentrations of phosphorus may result in a reduction of serum calcium and symptoms of hypocalcemic tetany. Calcium levels should be monitored. Solutions containing sodium ions should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency and in clinical states in which there exists edema with sodium retention. In patients with diminished renal function, administration of solutions containing sodium ions may result in sodium retention. WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum. Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.
Who should not take Sodium Phosphates
Sodium phosphate is contraindicated in diseases where high phosphorus or low calcium levels may be encountered, and in patients with hypernatremia.
Overdose — what happens if you take too much
In the event of overdosage, discontinue infusions containing sodium phosphate immediately and institute corrective therapy to restore depressed serum calcium and to reduce elevated serum sodium levels. See WARNINGS , PRECAUTIONS and ADVERSE REACTIONS .
U.S. Poison Control: call or text 1-800-222-1222 (free, 24/7). In an emergency call 911. From the FDA label; not medical advice.
Dosage forms
Injectable
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
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Frequently asked questions
- Is there a coupon or discount for Sodium Phosphates?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Sodium Phosphates. To pay less, Sodium Phosphates is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Sodium Phosphates?
- Sodium Phosphates is marketed by Am Regent. You can see Am Regent's full profile, rating, and other products on pharmaranks.
- Is Sodium Phosphates a brand-name or generic drug?
- Sodium Phosphates is a generic medication; its active ingredient is Sodium Phosphate, Dibasic, Heptahydrate and Sodium Phosphate, Monobasic, Monohydrate. Generics contain the same active ingredient as the brand-name original and are usually lower cost.
- Is Sodium Phosphates available over the counter?
- No. Sodium Phosphates is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Sodium Phosphates come in?
- Sodium Phosphates is currently marketed as injectable, per the FDA's National Drug Code Directory.
- Is Sodium Phosphates FDA-registered?
- Sodium Phosphates is on record with the U.S. FDA under application number ANDA218314. You can verify this on its official FDA label.
- Is Sodium Phosphates safe?
- There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Sodium Phosphates. Review its FDA-label side effects and warnings below, and always consult a licensed professional.
- What are the side effects of Sodium Phosphates?
- Sodium Phosphates's side effects are taken directly from its FDA label. From the label: Adverse reactions involve the possibility of phosphorus intoxication. Phosphorus intoxication results in a reduction of serum calcium and the symptoms are those of hypocalcemic tetany. See WARNINGS . To report SUSPECTED ADVERSE REACTIONS, contact American Regent, Inc.… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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