protamine sulfate
Protamine Sulfate is a heparin reversal agent.
Heparin Reversal Agent · by Quad Pharms
Key facts
- Active ingredient
- Protamine Sulfate
- Drug class
- Heparin Reversal Agent
- Form
- Injectable
- Strength
- Protamine Sulfate 50MG/VIAL
- Type
- Prescription (Rx)
- Brand or generic
- Generic
- Manufacturer
- Quad Pharms
- FDA application
- ANDA089307
- Availability
- Discontinued (per FDA)
Drug class
Dosage forms
Injectable
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
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Frequently asked questions
- Is there a coupon or discount for Protamine Sulfate?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Protamine Sulfate. To pay less, Protamine Sulfate is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Protamine Sulfate?
- Protamine Sulfate is marketed by Quad Pharms. You can see Quad Pharms's full profile, rating, and other products on pharmaranks.
- Is Protamine Sulfate a brand-name or generic drug?
- Protamine Sulfate is a generic medication; its active ingredient is Protamine Sulfate. Generics contain the same active ingredient as the brand-name original and are usually lower cost.
- Is Protamine Sulfate available over the counter?
- No. Protamine Sulfate is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Protamine Sulfate come in?
- Protamine Sulfate is currently marketed as injectable, per the FDA's National Drug Code Directory.
- What class of drug is Protamine Sulfate?
- Protamine Sulfate is classified as heparin reversal agent, per the FDA's Established Pharmacologic Class.
- Is Protamine Sulfate FDA-registered?
- Protamine Sulfate is on record with the U.S. FDA under application number ANDA089307. You can verify this on its official FDA label.
Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
What people report to the FDA about Protamine Sulfate
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 1,998 reports naming Protamine Sulfate, and the FDA flagged 93% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- renal failure1,007 reports
- injury970 reports
- anxiety901 reports
- fear836 reports
- renal injury728 reports
- emotional distress707 reports
- anhedonia624 reports
- renal impairment591 reports
Read these as a signal, not a rate. A report does not mean Protamine Sulfate caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.
Source: openFDA drug/event (FAERS), retrieved September 26, 2026.
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