isoproterenol hydrochloride
Pharmaranks rates Isoproterenol Hydrochloride 3.5/5 for recall safety — an independent score from its FDA recall history and its manufacturer's record. Isoproterenol Hydrochloride is a beta-adrenergic agonist used to treat Adams-Stokes Syndrome, Bradycardia, Low Cardiac Output, Heart Arrest.
Beta-Adrenergic Agonist · by Cipla
Generic of Norisodrine Aerotrol
Based on 1 source · Recall-safety score from FDA recall history — this product's own recalls and its manufacturer's record. Not an efficacy or quality rating. methodology →
Key facts
- Active ingredient
- Isoproterenol Hydrochloride
- Drug class
- Beta-Adrenergic Agonist
- Form
- Injectable, Solution
- Strength
- Isoproterenol Hydrochloride 0.2MG/ML
- Type
- Prescription (Rx)
- Brand or generic
- Generic
- May treat
- adams-stokes syndrome, bradycardia, low cardiac output
- Manufacturer
- Cipla
- FDA application
- ANDA211738
- Availability
- Discontinued (per FDA)
What is Isoproterenol Hydrochloride?
From the FDA label:Isoproterenol hydrochloride is 3,4-Dihydroxy-α-[(isopropylamino)methyl] benzyl alcohol hydrochloride, a beta-adrenergic agonist and a synthetic sympathomimetic amine that is structurally related to epinephrine. The molecular formula is C 11 H 17 NO 3 · HCl. It has a molecular weight of 247.72 and the following structural formula: Isoproterenol hydrochloride is a racemic compound. Each milliliter of the sterile solution contains: Isoproterenol hydrochloride, USP 0.2 mg Edetate Disodium (EDTA) 0.2 mg Sodium Citrate Dihydrate 2.07 mg Citric Acid, Anhydrous 2.5 mg Sodium Chloride 7.0 mg Water for Injection qs 1.0 mL The pH is adjusted between 2.5 and 4.5 with hydrochloric acid and/or sodium hydroxide. The sterile solution is nonpyrogenic and can be administered by the intravenous route. structure
How to use
Isoproterenol Hydrochloride is sold in more than one form (Injectable and Solution), and each is dosed differently. The instructions below come from the FDA label for application ANDA211738 — follow the label that came with the product you were actually prescribed.
Initiate Isoproterenol Hydrochloride Injection, USP at the lowest recommended dose and increase gradually based on patient response ( 2.2 ) Recommended initial dosage: • Shock: 0.5 mcg to 5 mcg per minute as an intravenous infusion ( 2.2 ) • Bronchospasm: 10 mcg to 20 mcg intravenous injection ( 2.2 ) 2.1 General Considerations Inspect visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if the injection is pinkish or darker than slightly yellow or contains a precipitate. Discard any unused portion. Diluted solution should be used immediately. Unused material should be discarded. 2.2 Recommended Dosage Dosage should generally be started at the lowest recommended dose and increased gradually based on patient response. Recommended dosage for adults with shock and hypoperfusion states: Route of Administration Preparation of Dilution† Infusion Rate†† Intravenous infusion Dilute 5 mL (1 mg) in 500 mL of 5% Dextrose Injection, USP 0.5 mcg to 5 mcg per minute (0.25 mL to 2.5 mL of diluted solution) †Concentrations up to 10 times greater have been used when limitation of volume is essential. ††Rates over 30 mcg per minute have been used in advanced stages of shock. Adjust the rate of infusion based on heart rate, central venous pressure, systemic blood pressure, and urine flow. If the heart rate exceeds 110 beats…
Side effects
The following adverse reactions have been associated with use of isoproterenol. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure. Nervous system disorders : Nervousness, headache, dizziness, visual blurring Cardiovascular : Tachycardia, tachyarrhythmias, palpitations, angina, ventricular arrhythmias, Adams-Stokes attacks, pulmonary edema Respiratory : Dyspnea Other : Flushing of the skin, sweating, mild tremors, pallor, nausea Common adverse reactions with isoproterenol include tachycardia and palpitations ( 6 ) To report SUSPECTED ADVERSE REACTIONS, contact Amphastar Pharmaceuticals, Inc. at 1-800-423-4136 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Warnings
Important safety information
Cardiac arrhythmias and ischemia may be induced by Isoproterenol Hydrochloride Injection, USP ( 5.1 ) 5.1 Cardiac Arrhythmias and Ischemia Isoproterenol may induce cardiac arrhythmias and myocardial ischemia in patients, especially patients with coronary artery disease, or cardiomyopathy.
Who should not take Isoproterenol Hydrochloride
Isoproterenol Hydrochloride Injection, USP is contraindicated in patients with: • tachycardia • ventricular arrhythmias • angina pectoris Isoproterenol Hydrochloride Injection, USP is contraindicated in patients with: • Tachycardia ( 4 ) • Ventricular arrhythmias ( 4 ) • Angina pectoris ( 4 )
Overdose — what happens if you take too much
Overdosage of isoproterenol can cause tachycardia or other arrhythmias, palpitations, angina, hypotension, or hypertension. In case of overdosage, reduce the rate of administration or discontinue isoproterenol hydrochloride injection until patient’s condition stabilizes. Monitor blood pressure, pulse, respiration, and EKG. It is not known whether isoproterenol hydrochloride is dialyzable.
U.S. Poison Control: call or text 1-800-222-1222 (free, 24/7). In an emergency call 911. From the FDA label; not medical advice.
Interactions
Table 1. Clinically Relevant Interactions with Isoproterenol Epinephrine Clinical Impact Both drugs are direct cardiac stimulants, and their combined effects may induce serious arrhythmias upon simultaneous administration. Intervention Isoproterenol hydrochloride injection and epinephrine should not be administered simultaneously. Drugs that may potentiate clinical response of Isoproterenol Clinical Impact The effects of isoproterenol may be potentiated by tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium, and certain antihistamines, notably chlorpheniramine, tripelennamine, and diphenhydramine. Intervention Monitor hemodynamic parameters in patients who concurrently are taking tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium and certain antihistamines. Adjust doses appropriately. Drugs that may reduce clinical response of Isoproterenol Clinical Impact The cardiostimulating and bronchodilating effects of isoproterenol are antagonized by beta-adrenergic blocking drugs, such as propranolol. Intervention Monitor for hemodynamic response and relief of bronchospasm and adjust dose appropriately. • Do not administer Isoproterenol Hydrochloride Injection, USP and epinephrine simultaneously due to combined effects may induce serious arrhythmias ( 7 ) • Concomitant use of tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium and certain antihistamines; hemodynamic parameters may potentiate a clinical response of isoproterenol ( 7 ) • Beta-adrenergic blocking drugs may reduce cardiostimulating and bronchodilating effects of isoproterenol ( 7 ) See 17 for PATIENT COUNSELING INFORMATION.
Drug class
May treat (source: NIH RxClass)
- adams-stokes syndrome
- bradycardia
- low cardiac output
- heart arrest
- hemorrhagic shock
- septic shock
Dosage forms
Injectable and Solution
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
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Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
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Frequently asked questions
- What does Isoproterenol Hydrochloride treat?
- Isoproterenol Hydrochloride (Isoproterenol Hydrochloride) may be used to treat adams-stokes syndrome, bradycardia, low cardiac output, heart arrest, hemorrhagic shock, septic shock, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- How is Isoproterenol Hydrochloride rated?
- pharmaranks gives Isoproterenol Hydrochloride a composite score of 3.5 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.
- Is there a coupon or discount for Isoproterenol Hydrochloride?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Isoproterenol Hydrochloride. To pay less, Isoproterenol Hydrochloride is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Isoproterenol Hydrochloride?
- Isoproterenol Hydrochloride is marketed by Cipla. You can see Cipla's full profile, rating, and other products on pharmaranks.
- Is Isoproterenol Hydrochloride a brand-name or generic drug?
- Isoproterenol Hydrochloride is a generic medication; its active ingredient is Isoproterenol Hydrochloride. Generics contain the same active ingredient as the brand-name original and are usually lower cost.
- Is Isoproterenol Hydrochloride available over the counter?
- No. Isoproterenol Hydrochloride is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Isoproterenol Hydrochloride come in?
- Isoproterenol Hydrochloride is currently marketed as injectable and solution, per the FDA's National Drug Code Directory.
- What class of drug is Isoproterenol Hydrochloride?
- Isoproterenol Hydrochloride is classified as beta-adrenergic agonist, per the FDA's Established Pharmacologic Class.
- Is Isoproterenol Hydrochloride FDA-registered?
- Isoproterenol Hydrochloride is on record with the U.S. FDA under application number ANDA211738. You can verify this on its official FDA label.
- Has Isoproterenol Hydrochloride been recalled by the FDA?
- Isoproterenol Hydrochloride has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.
- Is Isoproterenol Hydrochloride safe?
- There's no single safe-or-not verdict. pharmaranks gives Isoproterenol Hydrochloride a recall-safety score of 70/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.
- What are the side effects of Isoproterenol Hydrochloride?
- Isoproterenol Hydrochloride's side effects are taken directly from its FDA label. From the label: The following adverse reactions have been associated with use of isoproterenol. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure.… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
What people report to the FDA about Isoproterenol Hydrochloride
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 213 reports naming Isoproterenol Hydrochloride, and the FDA flagged 91% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- toxic epidermal necrolysis20 reports
- ventricular fibrillation13 reports
- atrial fibrillation11 reports
- torsade de pointes11 reports
- electrocardiogram qt prolonged10 reports
- bradycardia8 reports
- dyspnoea8 reports
- hypotension8 reports
Read these as a signal, not a rate. A report does not mean Isoproterenol Hydrochloride caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.
Source: openFDA drug/event (FAERS), retrieved September 25, 2026.
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isoproterenol hydrochloride
70/100