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Pharmaranks rates Ismelin 3.5/5 for recall safety — an independent score from its FDA recall history and its manufacturer's record. Ismelin (Guanethidine Monosulfate) is a medication used to treat Hypertension.

Guanethidine Monosulfate · by Novartis

70/100Limited · 1 source

Based on 1 source · Recall-safety score from FDA recall history — this product's own recalls and its manufacturer's record. Not an efficacy or quality rating. methodology →

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate
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Key facts

Active ingredient
Guanethidine Monosulfate
Form
Tablet
Strength
Guanethidine Monosulfate EQ 10MG Sulfate · Guanethidine Monosulfate EQ 25MG Sulfate
Type
Prescription (Rx)
Brand or generic
Brand-name
May treat
hypertension
Manufacturer
Novartis
FDA application
NDA012329
Availability
Discontinued (per FDA)

May treat (source: NIH RxClass)

Dosage forms

Tablet

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

What does Ismelin treat?
Ismelin (Guanethidine Monosulfate) may be used to treat hypertension, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How is Ismelin rated?
pharmaranks gives Ismelin a composite score of 3.5 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.
Is there a coupon or discount for Ismelin?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Ismelin. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Ismelin?
Ismelin is marketed by Novartis. You can see Novartis's full profile, rating, and other products on pharmaranks.
Is Ismelin a brand-name or generic drug?
Ismelin is a brand-name product with the active ingredient Guanethidine Monosulfate.
Is Ismelin available over the counter?
No. Ismelin is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Ismelin come in?
Ismelin is currently marketed as tablet, per the FDA's National Drug Code Directory.
Is Ismelin FDA-registered?
Ismelin is on record with the U.S. FDA under application number NDA012329. You can verify this on its official FDA label.
Has Ismelin been recalled by the FDA?
Ismelin has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.
Is Ismelin safe?
There's no single safe-or-not verdict. pharmaranks gives Ismelin a recall-safety score of 70/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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