indium in 111 oxyquinoline
Indium in 111 Oxyquinoline (Indium in-111 Oxyquinoline) is a medication supplied as a liquid and solution.
Indium in-111 Oxyquinoline · by Ge Healthcare
Key facts
- Active ingredient
- Indium in-111 Oxyquinoline
- Form
- Liquid, Solution
- Strength
- Indium IN-111 Oxyquinoline 1mCi/ML
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- Manufacturer
- Ge Healthcare
- FDA application
- NDA019044
What is Indium in 111 Oxyquinoline?
From the FDA label:Indium In 111 Oxyquinoline (oxine) Solution is a diagnostic radiopharmaceutical intended for radiolabeling autologous leukocytes. It is supplied as a sterile, non-pyrogenic, isotonic aqueous solution with a pH range of 6.5 to 7.5 [sodium hydroxide and hydrochloric acid may be used to adjust the pH]. Each mL of the solution contains 37 MBq, 1 mCi of indium In 111 [no carrier added, >1.85 GBq/mcg indium (>50 mCi/mcg indium)] at calibration time, 50 mcg oxyquinoline, 100 mcg polysorbate 80, and 6 mg of HEPES (N-2-hydroxyethyl-piperazine-N'-2-ethane sulfonic acid) buffer in 0.75% Sodium Chloride Solution. The drug is intended to be used as a single-dose vial and contains no bacteriostatic agent. The radionuclidic impurity limit for indium 114m is not greater than 37 kBq, 1 µCi of indium 114m per 37 MBq, 1 mCi of indium In 111 at the time of calibration. The radionuclidic composition at expiration time is not less than 99.75% of indium In 111 and not more than 0.25% of indium In 114m/114. Chemical name: Indium In 111 Oxyquinoline. The precise structure of the indium In 111 oxyquinoline complex is unknown at this time. The empirical formula is (C 9 H 6 NO) 3 In 111.
How to use
Indium in 111 Oxyquinoline is sold in more than one form (Liquid and Solution), and each is dosed differently. The instructions below come from the FDA label for application NDA019044 — follow the label that came with the product you were actually prescribed.
The recommended adult (70 kg) dose of indium In 111 oxyquinoline labeled autologous leukocytes is 7.4 to 18.5 MBq, 200 to 500 µCi. Indium In 111 Oxyquinoline Solution is intended for the radiolabeling of autologous leukocytes. The indium In 111 oxyquinoline labeled autologous leukocytes are administered intravenously. Imaging is recommended at approximately 24 hours post injection. Typically, anterior and posterior views of the chest, abdomen and pelvis should be obtained with other views as required. Aseptic procedures and a shielded syringe should be employed in the withdrawal of Indium In 111 Oxyquinoline Solution from the vial. Similar procedures should be employed during the labeling procedure and the administration of the labeled leukocytes to the patient. The user should wear waterproof gloves during the entire procedure. The patient's dose should be measured by a suitable radioactivity calibration system immediately before administration. At this time, the leukocyte preparation should be checked for gross clumping and red blood cell contamination.
Side effects
Sensitivity reactions (urticaria) have been reported. The presence of fever may mask pyrogenic reactions from indium In 111 oxyquinoline labeled leukocytes. The possibility of delayed adverse reactions has not been studied.
Warnings
Important safety information
The content of the vial of Indium In 111 Oxyquinoline Solution is intended only for use in the preparation of indium In 111 oxyquinoline labeled autologous leukocytes, and is not to be administered directly. Autologous leukocyte labeling is not recommended in leukopenic patients because of the small number of available leukocytes. Due to radiation exposure, indium In 111 oxyquinoline labeled leukocytes could cause fetal harm when administered to pregnant women. If this radiopharmaceutical is used during pregnancy, the patient should be informed of the potential hazard to the fetus. Indium In 111 oxyquinoline labeled autologous leukocytes should be used only when the benefit to be obtained exceeds the risks involved in children under eighteen years of age owing to the high radiation burden and the potential for delayed manifestation of long-term adverse effects.
Who should not take Indium in 111 Oxyquinoline
None known.
Dosage forms
Liquid and Solution
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
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Frequently asked questions
- Is there a coupon or discount for Indium in 111 Oxyquinoline?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Indium in 111 Oxyquinoline. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Indium in 111 Oxyquinoline?
- Indium in 111 Oxyquinoline is marketed by Ge Healthcare. You can see Ge Healthcare's full profile, rating, and other products on pharmaranks.
- Is Indium in 111 Oxyquinoline a brand-name or generic drug?
- Indium in 111 Oxyquinoline is a brand-name product with the active ingredient Indium in-111 Oxyquinoline.
- Is Indium in 111 Oxyquinoline available over the counter?
- No. Indium in 111 Oxyquinoline is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Indium in 111 Oxyquinoline come in?
- Indium in 111 Oxyquinoline is currently marketed as liquid and solution, per the FDA's National Drug Code Directory.
- Is Indium in 111 Oxyquinoline FDA-registered?
- Indium in 111 Oxyquinoline is on record with the U.S. FDA under application number NDA019044. You can verify this on its official FDA label.
- Is Indium in 111 Oxyquinoline safe?
- There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Indium in 111 Oxyquinoline. Review its FDA-label side effects and warnings below, and always consult a licensed professional.
- What are the side effects of Indium in 111 Oxyquinoline?
- Indium in 111 Oxyquinoline's side effects are taken directly from its FDA label. From the label: Sensitivity reactions (urticaria) have been reported. The presence of fever may mask pyrogenic reactions from indium In 111 oxyquinoline labeled leukocytes. The possibility of delayed adverse reactions has not been studied. Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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