hydralazine hydrochloride and hydrochlorothiazide
Hydralazine Hydrochloride and Hydrochlorothiazide is a combination medicine containing Hydralazine Hydrochloride and Hydrochlorothiazide.
Generic · by Solvay
Generic of Apresoline-Esidrix
Key facts
- Active ingredient
- Hydralazine Hydrochloride and Hydrochlorothiazide
- Form
- Capsule
- Strength
- Hydralazine Hydrochloride 25MG; Hydrochlorothiazide 25MG
- Type
- Prescription (Rx)
- Brand or generic
- Generic
- Manufacturer
- Solvay
- Half-life
- about 6 to 15 hours (the label reports a range, not a single number) (how long it stays in your system)
- What the pharmacy pays
- ~$1.11 for 30 — not your price
- FDA application
- ANDA087608
- Availability
- Discontinued (per FDA)
How long does Hydralazine Hydrochloride and Hydrochlorothiazide stay in your body?
The elimination half-life of hydralazine hydrochloride and hydrochlorothiazide is about 6 to 15 hours (the label reports a range, not a single number) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the plasma ELIMINATION half-life. Plasma levels fall bi-exponentially: other FDA labels for hydrochlorothiazide combination products describe a distribution phase of roughly 2 hours before the ~10-hour (6-15 h) elimination phase — the elimination figure is the one given here. Hydrochlorothiazide is NOT a prodrug and is NOT metabolized, so there is no active metabolite that outlasts the parent; more than 95% of the absorbed dose is excreted unchanged in urine. Kidney impairment: the label states plainly that in patients with renal disease plasma concentrations are increased and the elimination half-life is PROLONGED — it does not quantify by how much. The label does not state a different half-life for older adults or for liver impairment, so no number should be assumed for those groups. Absorption (not elimination) is reduced in congestive heart failure. This is a pharmacokinetic figure about how long the drug stays in plasma; it is not a drug-test detection window and not dosing guidance.
This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: DailyMed — HYDROCHLOROTHIAZIDE capsule, Clinical Pharmacology (Pharmacokinetics and Metabolism).
Dosage forms
Capsule
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
A same-class option may cost less. See alternatives →
Frequently asked questions
- How much does Hydralazine Hydrochloride and Hydrochlorothiazide cost?
- Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $1.11 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
- Is there a coupon or discount for Hydralazine Hydrochloride and Hydrochlorothiazide?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Hydralazine Hydrochloride and Hydrochlorothiazide. To pay less, Hydralazine Hydrochloride and Hydrochlorothiazide is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Hydralazine Hydrochloride and Hydrochlorothiazide?
- Hydralazine Hydrochloride and Hydrochlorothiazide is marketed by Solvay. You can see Solvay's full profile, rating, and other products on pharmaranks.
- Is Hydralazine Hydrochloride and Hydrochlorothiazide a brand-name or generic drug?
- Hydralazine Hydrochloride and Hydrochlorothiazide is a generic medication; its active ingredient is Hydralazine Hydrochloride and Hydrochlorothiazide. Generics contain the same active ingredient as the brand-name original and are usually lower cost.
- Is Hydralazine Hydrochloride and Hydrochlorothiazide available over the counter?
- No. Hydralazine Hydrochloride and Hydrochlorothiazide is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Hydralazine Hydrochloride and Hydrochlorothiazide come in?
- Hydralazine Hydrochloride and Hydrochlorothiazide is currently marketed as capsule, per the FDA's National Drug Code Directory.
- Is Hydralazine Hydrochloride and Hydrochlorothiazide FDA-registered?
- Hydralazine Hydrochloride and Hydrochlorothiazide is on record with the U.S. FDA under application number ANDA087608. You can verify this on its official FDA label.
Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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