hiprex
Hiprex (Methenamine Hippurate) is a medication used to treat Bacteriuria, Cystitis, Escherichia Coli Infections, Staphylococcal Infections.
Methenamine Hippurate · by Esjay Pharma
Key facts
- Active ingredient
- Methenamine Hippurate
- Form
- Tablet
- Strength
- Methenamine Hippurate 1GM
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- May treat
- bacteriuria, cystitis, escherichia coli infections
- Manufacturer
- Esjay Pharma
- FDA application
- NDA017681
What is Hiprex?
From the FDA label:Each yellow, capsule-shaped tablet contains 1 g Methenamine Hippurate, USP which is the hippuric acid salt of methenamine (hexamethylene tetramine). The tablet also contains inactive ingredients: FD&C Yellow No. 5 (tartrazine, see PRECAUTIONS ), magnesium stearate, povidone, and saccharin sodium.
How to use
DOSAGE & ADMINISTRATION 1 tablet (1.0 g) twice daily (morning and night) for adults and pediatric patients over 12 years of age. 1/2 to 1 tablet (0.5 to 1.0 g) twice daily (morning and night) for pediatric patients 6 to 12 years of age. Since the antibacterial activity of methenamine hippurate tablets is greater in acid urine, restriction of alkalinizing foods and medications is desirable. If necessary, as indicated by urinary pH and clinical response, supplemental acidification of the urine should be instituted. The efficacy of therapy should be monitored by repeated urine cultures.
Side effects
Minor adverse reactions have been reported in less than 3.5% of patients treated. These reactions have included nausea, upset stomach, dysuria, and rash. To report SUSPECTED ADVERSE REACTIONS, contact ANI Pharmaceuticals, Inc. at 1-855-204-1431 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Warnings
Important safety information
Large doses of methenamine (8 grams daily for 3 to 4 weeks) have caused bladder irritation, painful and frequent micturition, albuminuria, and gross hematuria.
Who should not take Hiprex
Methenamine hippurate tablets are contraindicated in patients with renal insufficiency, severe hepatic insufficiency, or severe dehydration. Methenamine preparations should not be given to patients taking sulfonamides because some sulfonamides may form an insoluble precipitate with formaldehyde in the urine.
May treat (source: NIH RxClass)
Dosage forms
Tablet
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
A same-class option may cost less. See alternatives →
Frequently asked questions
- What does Hiprex treat?
- Hiprex (Methenamine Hippurate) may be used to treat bacteriuria, cystitis, escherichia coli infections, staphylococcal infections, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- Is there a coupon or discount for Hiprex?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Hiprex. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Hiprex?
- Hiprex is marketed by Esjay Pharma. You can see Esjay Pharma's full profile, rating, and other products on pharmaranks.
- Is Hiprex a brand-name or generic drug?
- Hiprex is a brand-name product with the active ingredient Methenamine Hippurate.
- Is Hiprex available over the counter?
- No. Hiprex is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Hiprex come in?
- Hiprex is currently marketed as tablet, per the FDA's National Drug Code Directory.
- Is Hiprex FDA-registered?
- Hiprex is on record with the U.S. FDA under application number NDA017681. You can verify this on its official FDA label.
- Is Hiprex safe?
- There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Hiprex. Review its FDA-label side effects and warnings below, and always consult a licensed professional.
- What are the side effects of Hiprex?
- Hiprex's side effects are taken directly from its FDA label. From the label: Minor adverse reactions have been reported in less than 3.5% of patients treated. These reactions have included nausea, upset stomach, dysuria, and rash. To report SUSPECTED ADVERSE REACTIONS, contact ANI Pharmaceuticals, Inc. at 1-855-204-1431 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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