edarbyclor

What is Edarbyclor?

From the FDA label:Edarbyclor is a combination of azilsartan medoxomil (angiotensin II receptor blocker; as its potassium salt) and chlorthalidone (thiazide-like diuretic). Azilsartan medoxomil, a prodrug, is hydrolyzed to azilsartan in the gastrointestinal tract during absorption. Azilsartan is an angiotensin II receptor blocker. Chlorthalidone is a monosulfamyl thiazide-like diuretic that differs chemically from thiazide diuretics by the lack of a benzothiadiazine structure. The potassium salt of azilsartan medoxomil, azilsartan kamedoxomil, is chemically described as (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1 H -benzimidazole-7-carboxylate monopotassium salt. Its empirical formula is C 30 H 23 KN 4 O 8. Chlorthalidone is chemically described as 2-chloro-5(1-hydroxy-3-oxo-1- isoindolinyl) benzenesulfonamide. Its empirical formula is C 14 H 11 ClN 2 O 4 S. The structural formula for azilsartan medoxomil is The structural formula for chlorthalidone is Azilsartan kamedoxomil is a white to nearly white powder with a molecular weight of 606.62. It is practically insoluble in water and freely soluble in methanol. Chlorthalidone is a white to yellowish white powder with a molecular weight of 338.76. Chlorthalidone is practically insoluble in water, in ether, and in chloroform; soluble in methanol; slightly soluble in ethanol.…

How to use

Side effects

FDA Boxed Warning (the FDA’s most serious warning)

Warnings

Who should not take Edarbyclor

Overdose — what happens if you take too much

Interactions

How long does Azilsartan Kamedoxomil and Chlorthalidone stay in your body?

The elimination half-life of azilsartan kamedoxomil and chlorthalidone is about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is an older-format label (CLINICAL PHARMACOLOGY, not a PLR §12.3), and it gives its numbers in two ways: a mean half-life of 40 hours across the 50–200 mg dose range, and dose-specific elimination half-lives of 53 hours (50 mg) and 60 hours (100 mg). Only one phase is described, so the figures above are the elimination values the label states — it does not report a separate distribution phase. No active metabolite is described: the label says chlorthalidone is largely excreted unchanged by the kidneys and that data on metabolites and non-renal elimination routes "have yet to be clarified." It is not a prodrug. Do not confuse the half-life with the duration of diuretic effect — the label describes diuresis beginning in about 2.6 hours and continuing up to 72 hours, which is a different measure. The label does NOT quantify how the half-life changes with age, kidney impairment, or liver impairment; it gives no geriatric or renal/hepatic pharmacokinetic numbers. It does warn that cumulative effects of the drug may develop in patients with impaired renal function, and to use caution in severe renal disease and in impaired hepatic function — but it does not state a half-life for those groups, so no number should be inferred for them.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: DailyMed — CHLORTHALIDONE tablet (Clinical Pharmacology).

Frequently asked questions

How is Edarbyclor rated?

pharmaranks gives Edarbyclor a composite score of 3.5 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.

Is there a coupon or discount for Edarbyclor?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Edarbyclor. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Edarbyclor?

Edarbyclor is marketed by Azurity. You can see Azurity's full profile, rating, and other products on pharmaranks.

Is Edarbyclor a brand-name or generic drug?

Edarbyclor is a brand-name product with the active ingredient Azilsartan Kamedoxomil and Chlorthalidone.

Is Edarbyclor available over the counter?

No. Edarbyclor is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Edarbyclor come in?

Edarbyclor is currently marketed as tablet, per the FDA's National Drug Code Directory.

Is Edarbyclor FDA-registered?

Edarbyclor is on record with the U.S. FDA under application number NDA202331. You can verify this on its official FDA label.

Has Edarbyclor been recalled by the FDA?

Yes. Edarbyclor has 1 recorded FDA recall event in the openFDA enforcement database. A recall removes specific lots from the market — usually for manufacturing, contamination, potency, or labeling issues — and does not mean the drug is unsafe to take; your specific lot was almost certainly never affected. This recall history is factored into its safety score above. Always check the FDA recall database or your pharmacist for current alerts.

Is Edarbyclor safe?

There's no single safe-or-not verdict. pharmaranks gives Edarbyclor a recall-safety score of 70/100, based on its FDA recall history (1 recorded recall event) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.

What are the side effects of Edarbyclor?

Edarbyclor's side effects are taken directly from its FDA label. From the label: The following potential adverse reactions with Edarbyclor, azilsartan medoxomil, or chlorthalidone and similar agents are included in more detail in the Warnings and Precautions section of the label: Fetal toxicity [see Warnings and Precautions (5.1) ] Hypotension in Volume- or Salt-Depleted Patient… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.