Key facts
- Active ingredient
- Doxazosin Mesylate
- Drug class
- Alpha-Adrenergic Blocker
- Form
- Tablet
- Strength
- Doxazosin Mesylate EQ 1MG Base · Doxazosin Mesylate EQ 2MG Base · Doxazosin Mesylate EQ 4MG Base · Doxazosin Mesylate EQ 8MG Base
- Type
- Prescription (Rx)
- Brand or generic
- Generic
- May treat
- hypertension, prostatic hyperplasia, urinary retention
- Manufacturer
- Pliva
- Half-life
- about 22 hours (terminal/beta phase) (how long it stays in your system)
- What the pharmacy pays
- ~$2.51 for 30 — not your price
- FDA application
- ANDA075750
- Availability
- Discontinued (per FDA)
How long does Doxazosin Mesylate stay in your body?
The elimination half-life of doxazosin mesylate is about 22 hours (terminal/beta phase) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. The label states plasma elimination is biphasic and reports the terminal (beta) elimination half-life of about 22 hours — not the distribution phase. The parent compound doxazosin is primarily responsible for the drug's activity; several active metabolites exist but circulate at low concentrations and their pharmacokinetics have not been characterized, so no active metabolite is reported to outlast the parent. Populations: half-life is unchanged in older adults (65+ vs under 65 are similar) and in renal impairment (no significant alterations). Hepatic impairment: mild cirrhosis (Child-Pugh A) raises doxazosin exposure ~40%; the effect of moderate-to-severe (Child-Pugh B/C) impairment is not known.
This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: Doxazosin label — DailyMed (Clinical Pharmacology 12.3, Excretion).
Drug class
How this class works, per Alpha-Blockers - StatPearls - NCBI Bookshelf.
May treat (source: NIH RxClass)
See how Doxazosin Mesylate ranks — best-rated alpha-adrenergic blocker for:
Dosage forms
Tablet
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
A same-class option may cost less. See alternatives →
Frequently asked questions
- What does Doxazosin Mesylate treat?
- Doxazosin Mesylate (Doxazosin Mesylate) may be used to treat hypertension, prostatic hyperplasia, urinary retention, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- How does Doxazosin Mesylate work?
- Doxazosin Mesylate is a alpha-adrenergic blocker. Alpha-adrenergic blockers block the alpha-1 receptors that adrenaline-like signals use to tighten muscle in blood vessels and the prostate. This relaxes those muscles, lowering blood pressure and easing urine flow in men with an enlarged prostate.
- How much does Doxazosin Mesylate cost?
- Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $2.51 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins. Pharmacies pay less for a same-class option, Coreg — about $0.63 on the same basis.
- Is there a coupon or discount for Doxazosin Mesylate?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Doxazosin Mesylate. To pay less, Doxazosin Mesylate is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Doxazosin Mesylate?
- Doxazosin Mesylate is marketed by Pliva. You can see Pliva's full profile, rating, and other products on pharmaranks.
- Is Doxazosin Mesylate a brand-name or generic drug?
- Doxazosin Mesylate is a generic medication; its active ingredient is Doxazosin Mesylate. Generics contain the same active ingredient as the brand-name original and are usually lower cost.
- Is Doxazosin Mesylate available over the counter?
- No. Doxazosin Mesylate is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Doxazosin Mesylate come in?
- Doxazosin Mesylate is currently marketed as tablet, per the FDA's National Drug Code Directory.
- What class of drug is Doxazosin Mesylate?
- Doxazosin Mesylate is classified as alpha-adrenergic blocker, per the FDA's Established Pharmacologic Class.
- Is Doxazosin Mesylate FDA-registered?
- Doxazosin Mesylate is on record with the U.S. FDA under application number ANDA075750. You can verify this on its official FDA label.
Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
What people report to the FDA about Doxazosin Mesylate
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 7,991 reports naming Doxazosin Mesylate, and the FDA flagged 80% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- dyspnoea538 reports
- fatigue445 reports
- diarrhoea411 reports
- dizziness381 reports
- asthma348 reports
- hypotension306 reports
- nausea306 reports
- asthenia297 reports
Read these as a signal, not a rate. A report does not mean Doxazosin Mesylate caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.
Source: openFDA drug/event (FAERS), retrieved September 25, 2026.
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