dolutegravir, lamivudine and tenofovir disoproxil fumarate

How long does Dolutegravir and Lamivudine and Tenofovir Disoproxil Fumarate stay in your body?

The elimination half-life of dolutegravir and lamivudine and tenofovir disoproxil fumarate is about 14 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the terminal (elimination) half-life, which the TIVICAY label gives as "approximately 14 hours," based on population pharmacokinetic analyses; the label reports no separate distribution-phase half-life. Dolutegravir is not a prodrug, and the label describes no active metabolite — it is metabolized mainly by UGT1A1 (with some CYP3A) to an ether glucuronide and oxidative metabolites that the label does not characterize as active, and just over half the dose leaves unchanged in the feces. On populations the label names: age had no clinically relevant effect on dolutegravir pharmacokinetics; mild and moderate kidney impairment had no clinically relevant effect on exposure, and in severe kidney impairment (CrCl under 30 mL/min) exposure was actually lower, not higher (AUC down 40%), with too little information to recommend dosing in people on dialysis; in moderate liver impairment (Child-Pugh B) exposure was similar to healthy controls, and severe liver impairment (Child-Pugh C) has not been studied. The label frames these as changes in exposure rather than stating a revised half-life for each group. People with UGT1A1 genotypes conferring poor metabolism had 32% lower clearance and 46% higher AUC. This figure describes how long the drug itself is cleared from plasma — it is not a drug-test detection window (metabolites can be detected far longer) and not dosing guidance.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: DailyMed — TIVICAY (dolutegravir sodium) tablet, film coated — Clinical Pharmacology (12.3).

Frequently asked questions

Is there a coupon or discount for Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate?

Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate is marketed by Shanghai Desana Bio-Pharmaceuticals Co Ltd. You can see Shanghai Desana Bio-Pharmaceuticals Co Ltd's full profile, rating, and other products on pharmaranks.

Is Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate a brand-name or generic drug?

Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate is a brand-name product with the active ingredient Dolutegravir and Lamivudine and Tenofovir Disoproxil Fumarate.

Is Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate available over the counter?

No. Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate come in?

Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate is currently marketed as tablet, per the FDA's National Drug Code Directory.

Is Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate FDA-registered?

Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate is on record with the U.S. FDA under application number NDA213556. You can verify this on its official FDA label.