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allegra-d 24 hour allergy and congestion

Allegra-D 24 Hour Allergy and Congestion is a combination medicine containing Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride.

Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride · by Chattem Sanofi

Available as a generic: Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass
~$7.44 /30
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Key facts

Active ingredient
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride
Form
Tablet, extended release
Strength
Fexofenadine Hydrochloride 180MG; Pseudoephedrine Hydrochloride 240MG
Type
Over-the-counter (OTC)
Brand or generic
Brand-name
Manufacturer
Chattem Sanofi
Half-life
roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline) (how long it stays in your system)
What the pharmacy pays
~$7.44 for 30 — not your price
FDA application
NDA021704

What is Allegra-D 24 Hour Allergy and Congestion?

From the FDA label:Uses temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: ▪ runny nose ▪ sneezing ▪ itchy, watery eyes ▪ itching of the nose or throat temporarily relieves nasal congestion due to the common cold, hay fever or other upper respiratory allergies reduces swelling of nasal passages temporarily relieves sinus congestion and pressure temporarily restores freer breathing through the nose

How to use

Directions do not divide, crush, chew or dissolve the tablet; swallow tablet whole adults and children 12 years of age and over take 1 tablet with a glass of water every 24 hours on an empty stomach; do not take more than 1 tablet in 24 hours children under 12 years of age do not use adults 65 years of age and older ask a doctor consumers with kidney disease ask a doctor

Warnings

Important safety information

Do not use if you have ever had an allergic reaction to this product or any of its ingredients if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. If you have difficulty swallowing Ask a doctor before use if you have heart disease thyroid disease glaucoma high blood pressure diabetes trouble urinating due to an enlarged prostate gland kidney disease. Your doctor should determine if you need a different dose. When using this product do not take more than directed do not take at the same time as aluminum or magnesium antacids do not take with fruit juices (see Directions ) the tablet coating may be seen in the stool (this is normal). Continue to take as directed (see Directions ). Stop use and ask a doctor if an allergic reaction to this product occurs. Seek medical help right away. symptoms do not improve within 7 days or are accompanied by a fever you get nervous, dizzy, or sleepless If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

How long does Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride stay in your body?

The elimination half-life of fexofenadine hydrochloride and pseudoephedrine hydrochloride is roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is a genuinely variable half-life, not a fixed one. Pseudoephedrine is cleared mostly unchanged by the kidneys (55% to 96% of a dose appears unchanged in urine), and because it is a base, acidic urine traps and flushes it out faster while alkaline urine lets it be reabsorbed — hence the 3-6 h vs 9-16 h spread the label reports. No active metabolite to worry about: the label says less than 1% is metabolized in the liver, by N-demethylation, to an INACTIVE metabolite. It is not a prodrug. Kidney impairment: because clearance is renal, the label states pseudoephedrine "may accumulate in patients with renal impairment," and the product is to be generally avoided in these patients — expect a longer half-life, though the label does not quantify it. Liver impairment: no studies of pseudoephedrine were conducted in hepatic impairment, so the label gives no number; the product is likewise to be generally avoided. Older adults: this label gives no separate pseudoephedrine half-life for people 65+ (its geriatric pharmacokinetic data covers the antihistamine component only), but it warns that older adults are more likely to have adverse reactions to sympathomimetic amines. The half-life above is from the Clarinex-D 12 Hour label, which is where FDA-approved pseudoephedrine pharmacokinetics are published; standalone OTC pseudoephedrine products carry monograph "Drug Facts" labels that contain no pharmacokinetics section at all.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: CLARINEX-D 12 HOUR (desloratadine and pseudoephedrine sulfate) extended release tablets — Section 12.3 Pharmacokinetics, DailyMed.

Dosage forms

Tablet, extended release

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

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Frequently asked questions

How much does Allegra-D 24 Hour Allergy and Congestion cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $7.44 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Allegra-D 24 Hour Allergy and Congestion?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Allegra-D 24 Hour Allergy and Congestion. To pay less, look for a store-brand version with the same active ingredient (Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride), which is typically cheaper, and compare unit prices. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Allegra-D 24 Hour Allergy and Congestion?
Allegra-D 24 Hour Allergy and Congestion is marketed by Chattem Sanofi. You can see Chattem Sanofi's full profile, rating, and other products on pharmaranks.
Is Allegra-D 24 Hour Allergy and Congestion a brand-name or generic drug?
Allegra-D 24 Hour Allergy and Congestion is a brand-name product with the active ingredient Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride. Lower-cost generic equivalents containing Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride are available — ask your pharmacist.
Is Allegra-D 24 Hour Allergy and Congestion available over the counter?
Yes. Allegra-D 24 Hour Allergy and Congestion is an over-the-counter (OTC) product — you can buy it without a prescription. Follow the label directions and ask a pharmacist if you're unsure whether it's right for you.
What forms does Allegra-D 24 Hour Allergy and Congestion come in?
Allegra-D 24 Hour Allergy and Congestion is currently marketed as tablet, extended release, per the FDA's National Drug Code Directory.
Is Allegra-D 24 Hour Allergy and Congestion FDA-registered?
Allegra-D 24 Hour Allergy and Congestion is on record with the U.S. FDA under application number NDA021704. You can verify this on its official FDA label.
Is Allegra-D 24 Hour Allergy and Congestion safe?
There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Allegra-D 24 Hour Allergy and Congestion. Review its FDA-label side effects and warnings below, and always consult a licensed professional.

Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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