acetaminophen and ibuprofen
Pharmaranks rates Acetaminophen and Ibuprofen 2.8/5 for recall safety — an independent score from its FDA recall history and its manufacturer's record. Acetaminophen and Ibuprofen is a combination medicine containing Acetaminophen and Ibuprofen.
Generic · by Glenmark Pharms Ltd
Generic of Combogesic
Based on 1 source · Recall-safety score from FDA recall history — this product's own recalls and its manufacturer's record. Not an efficacy or quality rating. methodology →
Key facts
- Active ingredient
- Acetaminophen and Ibuprofen
- Form
- Tablet
- Strength
- Acetaminophen 250MG; Ibuprofen 125MG
- Type
- Over-the-counter (OTC)
- Brand or generic
- Generic
- Manufacturer
- Glenmark Pharms Ltd
- Half-life
- about 1.8 to 2.0 hours (how long it stays in your system)
- What the pharmacy pays
- ~$0.03 per ml — not your price
- FDA application
- ANDA218311
What is Acetaminophen and Ibuprofen?
From the FDA label:Uses • temporarily relieves minor aches and pains due to: o headache o toothache o backache o menstrual cramps o muscular aches o minor pain of arthritis
How to use
Directions • do not take more than directed adults and children 12 years and over • take 2 caplets every 8 hours while symptoms persist children under 12 years • ask a doctor • do not take more than 6 caplets in 24 hours, unless directed by a doctor
Warnings
Important safety information
Acetaminophen liver damage warning: This product contains acetaminophen. Severe liver damage may occur if you take: • with other drugs containing acetaminophen • more than 6 caplets in 24 hours, which is the maximum daily amount for this product • 3 or more alcoholic drinks every day while using this product Acetaminophen allergy alert: may cause severe skin reactions. Symptoms may include: • skin reddening • blisters • rash If skin reaction occurs, stop use and seek medical help right away. NSAID allergy alert: ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: • hives • facial swelling • asthma (wheezing) • shock • skin reddening • rash • blisters If an allergic reaction occurs, stop use and seek medical help right away. NSAID stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you: • are age 60 or older • have had stomach ulcers or bleeding problems • take a blood thinning (anticoagulant) or steroid drug • take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others] • have 3 or more alcoholic drinks every day while using this product • take more or for a longer time than directed Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed. Do not use • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist • if you have ever had an allergic reaction to acetaminophen or any other pain reliever • right before or after heart surgery Ask a doctor before use if • you have liver disease • stomach bleeding warning applies to you • you have problems or serious side effects from taking pain relievers • you have a history of stomach problems, such as heartburn • you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke • you are taking a diuretic Ask a doctor or pharmacist before use if you are • under a doctor's care for any serious condition • taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin • taking any other drug When using this product • take with food or milk if stomach upset occurs Stop use and ask a doctor if • you experience any of the following signs of stomach bleeding: o feel faint o vomit blood o have bloody or black stools o have stomach pain that does not get better • you have symptoms of heart problems or stroke: o chest pain o trouble breathing o weakness in one part or side of body o slurred speech o leg swelling • pain gets worse or lasts more than 10 days • redness or swelling is present in the painful area • any new symptoms appear If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use ibuprofen at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
How long does Acetaminophen and Ibuprofen stay in your body?
The elimination half-life of acetaminophen and ibuprofen is about 1.8 to 2.0 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. The label states a single serum half-life of 1.8 to 2.0 hours — it does not split the curve into a distribution and a terminal phase, so this is the elimination figure. Ibuprofen is not a prodrug, and the label names no active metabolite that outlasts the parent: the two major urinary metabolites (metabolite A, a hydroxymethyl-propyl derivative, and metabolite B, a carboxypropyl derivative) are described only as excretion products, and the label notes that excretion is virtually complete 24 hours after the last dose. This label does not report a different half-life for older adults or for people with kidney or liver impairment; it only advises caution in patients 65 and older and in those with impaired renal or hepatic function, so any change in clearance in those groups is not quantified here. This is a pharmacokinetic figure about how fast the drug leaves the blood — it is not a dosing instruction and not a drug-test detection window.
This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: Ibuprofen tablets USP — FDA label, Clinical Pharmacology (DailyMed).
Dosage forms
Tablet
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
A same-class option may cost less. See alternatives →
Frequently asked questions
- How is Acetaminophen and Ibuprofen rated?
- pharmaranks gives Acetaminophen and Ibuprofen a composite score of 2.8 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.
- How much does Acetaminophen and Ibuprofen cost?
- Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.03 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
- Is there a coupon or discount for Acetaminophen and Ibuprofen?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Acetaminophen and Ibuprofen. To pay less, Acetaminophen and Ibuprofen is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Acetaminophen and Ibuprofen?
- Acetaminophen and Ibuprofen is marketed by Glenmark Pharms Ltd. You can see Glenmark Pharms Ltd's full profile, rating, and other products on pharmaranks.
- Is Acetaminophen and Ibuprofen a brand-name or generic drug?
- Acetaminophen and Ibuprofen is a generic medication; its active ingredient is Acetaminophen and Ibuprofen. Generics contain the same active ingredient as the brand-name original and are usually lower cost.
- Is Acetaminophen and Ibuprofen available over the counter?
- Yes. Acetaminophen and Ibuprofen is an over-the-counter (OTC) product — you can buy it without a prescription. Follow the label directions and ask a pharmacist if you're unsure whether it's right for you.
- What forms does Acetaminophen and Ibuprofen come in?
- Acetaminophen and Ibuprofen is currently marketed as tablet, per the FDA's National Drug Code Directory.
- Is Acetaminophen and Ibuprofen FDA-registered?
- Acetaminophen and Ibuprofen is on record with the U.S. FDA under application number ANDA218311. You can verify this on its official FDA label.
- Has Acetaminophen and Ibuprofen been recalled by the FDA?
- Yes. Acetaminophen and Ibuprofen has 1 recorded FDA recall event in the openFDA enforcement database. A recall removes specific lots from the market — usually for manufacturing, contamination, potency, or labeling issues — and does not mean the drug is unsafe to take; your specific lot was almost certainly never affected. This recall history is factored into its safety score above. Always check the FDA recall database or your pharmacist for current alerts.
- Is Acetaminophen and Ibuprofen safe?
- There's no single safe-or-not verdict. pharmaranks gives Acetaminophen and Ibuprofen a recall-safety score of 56/100, based on its FDA recall history (1 recorded recall event) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
What people report to the FDA about Acetaminophen and Ibuprofen
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 216 reports naming Acetaminophen and Ibuprofen, and the FDA flagged 7% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- drug effective for unapproved indication30 reports
- therapeutic product effect incomplete27 reports
- drug effect less than expected15 reports
- hypersensitivity7 reports
- drug hypersensitivity5 reports
- inappropriate schedule of product administration5 reports
- malaise4 reports
- somnolence4 reports
Read these as a signal, not a rate. A report does not mean Acetaminophen and Ibuprofen caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.
Source: openFDA drug/event (FAERS), retrieved September 25, 2026.
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acetaminophen and ibuprofen
56/100