Does ustekinumab-ttwe expire?
The printed date covers the sealed pack. Once ustekinumab-ttwe is opened, mixed or diluted, its label sets a second and usually much shorter limit — quoted below, per product.
Shortest limit on any ustekinumab-ttwe label: 35 days
“If not used within 35 days of room temperature storage, discard the prefilled syringe.”
That applies to the product it is printed on, not to every form of ustekinumab-ttwe — check which one you have against the list below.
What the labels say
“If not used within 35 days of room temperature storage, discard the prefilled syringe.”
On the label for USTEKINUMAB-TTWE · DailyMed
“If not used within 60 days, discard the prefilled syringe.”
On the label for USTEKINUMAB-TTWE · DailyMed
“If not used within 60 days, discard the prefilled syringe and prefilled PYZCHIVA AUTOINJECTOR.”
On the label for PYZCHIVA · DailyMed
How the label says to keep ustekinumab-ttwe
Storage is the other half of the question: the stability behind any date assumes these conditions, and a medicine kept outside them ages faster than the calendar says.
- “and Stability Store USTEKINUMAB-TTWE vials, and prefilled syringes refrigerated between 2°C to 8°C (36°F to 46°F).”
- “Store USTEKINUMAB-TTWE vials upright.”
- “Keep the product in the original carton to protect from light until the time of use.”
- “ringes may be stored at room temperature up to 30°C (86°F) for a maximum single period of up to 35 days in the original carton to protect from light.”
- “If not used within 35 days of room temperature storage, discard the prefilled syringe.”
- “Protect from light.”
- “The diluted infusion solution may be kept at room temperature up to 30°C (86°F) for up to 36 hours including infusion period.”
Frequently asked questions
Does ustekinumab-ttwe expire?
Two different clocks apply and only one of them is the printed date. The date on a sealed pack is the manufacturer's guarantee for the unopened product. Once it is opened, mixed or diluted, the label imposes its own limit — as tight as 35 days on some ustekinumab-ttwe products, and that is the number quoted on this page.
Can I still use ustekinumab-ttwe after the date on the box?
This page cannot tell you that, and nor can any page. The FDA's own shelf-life programme found 88% of tested lots stayed within specification at least a year past expiry — and concluded in the same breath that lot-to-lot variation means this can only be confirmed by testing each lot. What you can check at home is the in-use limit above and whether the product has been stored as the label requires. Ask a pharmacist about a specific pack; they will also dispose of what you no longer need.
Why do different ustekinumab-ttwe products have different limits?
Because they are different formulations. A suspension that gets mixed with water, a pen that gets carried at room temperature, and a sealed tablet do not behave alike, so each manufacturer's label sets its own limit and each is shown here with the product it belongs to. We never merge them into one number for the molecule.
More on ustekinumab-ttwe
Quoted from FDA labels for reference, not medical advice, and not a suggestion to use anything past its limit. If you are unsure whether a pack is still good, a pharmacist can tell you and can dispose of it safely.