Does filgrastim expire?
The printed date covers the sealed pack. Once filgrastim is opened, mixed or diluted, its label sets a second and usually much shorter limit — quoted below, per product.
Shortest limit on any filgrastim label: 24 hours
“Discard any vial or prefilled syringe left at room temperature for greater than 24 hours.”
That applies to the product it is printed on, not to every form of filgrastim — check which one you have against the list below.
What the labels say
“Discard any vial or prefilled syringe left at room temperature for greater than 24 hours.”
On the label for RELEUKO · DailyMed
How the label says to keep filgrastim
Storage is the other half of the question: the stability behind any date assumes these conditions, and a medicine kept outside them ages faster than the calendar says.
- “Store RELEUKO refrigerated at 2°C to 8°C (36°F to 46°F) in the original pack to protect from light.”
- “DO NOT freeze RELEUKO.”
- “This 4-hour time period includes the time during room temperature storage of the infusion solution and the duration of the infusion.”
- “16 HOW SUPPLIED/STORAGE AND HANDLING NEUPOGEN injection is a clear, colorless, preservative-free solution supplied as: Vials Single-dose vials containing 300 mcg/mL of filgrastim.”
- “Store NEUPOGEN at 2°C to 8°C (36°F to 46°F) in the carton to protect from light.”
- “This 24-hour time period includes the time during room temperature storage of the infusion solution and the duration of the infusion.”
Frequently asked questions
Does filgrastim expire?
Two different clocks apply and only one of them is the printed date. The date on a sealed pack is the manufacturer's guarantee for the unopened product. Once it is opened, mixed or diluted, the label imposes its own limit — as tight as 24 hours on some filgrastim products, and that is the number quoted on this page.
Can I still use filgrastim after the date on the box?
This page cannot tell you that, and nor can any page. The FDA's own shelf-life programme found 88% of tested lots stayed within specification at least a year past expiry — and concluded in the same breath that lot-to-lot variation means this can only be confirmed by testing each lot. What you can check at home is the in-use limit above and whether the product has been stored as the label requires. Ask a pharmacist about a specific pack; they will also dispose of what you no longer need.
Why do different filgrastim products have different limits?
Because they are different formulations. A suspension that gets mixed with water, a pen that gets carried at room temperature, and a sealed tablet do not behave alike, so each manufacturer's label sets its own limit and each is shown here with the product it belongs to. We never merge them into one number for the molecule.
More on filgrastim
Quoted from FDA labels for reference, not medical advice, and not a suggestion to use anything past its limit. If you are unsure whether a pack is still good, a pharmacist can tell you and can dispose of it safely.