Does bosentan expire?
The printed date covers the sealed pack. Once bosentan is opened, mixed or diluted, its label sets a second and usually much shorter limit — quoted below, per product.
Shortest limit on any bosentan label: 7 days
“Divided dispersible tablets should be stored under the same conditions and used within 7 days.”
That applies to the product it is printed on, not to every form of bosentan — check which one you have against the list below.
What the labels say
“Divided dispersible tablets should be stored under the same conditions and used within 7 days.”
On the label for Bosentan · DailyMed
How the label says to keep bosentan
Storage is the other half of the question: the stability behind any date assumes these conditions, and a medicine kept outside them ages faster than the calendar says.
- “16 HOW SUPPLIED/STORAGE AND HANDLING Bosentan Tablets are available as follows: 62.”
- “Store at 20°C to 25°C (68°F to 77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].”
- “Store at 20 ºC to 25 ºC (68 ºF to 77 ºF); excursions are permitted between 15°C and 30°C (59°F and 86°F).”
- “Keep out of reach of children.”
- “Store divided dispersible tablet pieces at 20 ºC to 25 ºC (68 ºF to 77 ºF) in the opened blister for up to 7 days.”
- “16 HOW SUPPLIED/STORAGE AND HANDLING 62.”
- “Store at 20 ºC to 25 ºC (68 ºF to 77 ºF).”
- “These storage temperatures apply to both film-coated and dispersible tablets.”
Frequently asked questions
Does bosentan expire?
Two different clocks apply and only one of them is the printed date. The date on a sealed pack is the manufacturer's guarantee for the unopened product. Once it is opened, mixed or diluted, the label imposes its own limit — as tight as 7 days on some bosentan products, and that is the number quoted on this page.
Can I still use bosentan after the date on the box?
This page cannot tell you that, and nor can any page. The FDA's own shelf-life programme found 88% of tested lots stayed within specification at least a year past expiry — and concluded in the same breath that lot-to-lot variation means this can only be confirmed by testing each lot. What you can check at home is the in-use limit above and whether the product has been stored as the label requires. Ask a pharmacist about a specific pack; they will also dispose of what you no longer need.
Why do different bosentan products have different limits?
Because they are different formulations. A suspension that gets mixed with water, a pen that gets carried at room temperature, and a sealed tablet do not behave alike, so each manufacturer's label sets its own limit and each is shown here with the product it belongs to. We never merge them into one number for the molecule.
More on bosentan
Quoted from FDA labels for reference, not medical advice, and not a suggestion to use anything past its limit. If you are unsure whether a pack is still good, a pharmacist can tell you and can dispose of it safely.