Technetium Tc-99m Tilmanocept: uses, dosing, side effects & brands
Technetium Tc-99m Tilmanocept is a medicine sold in the U.S. under one brand. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
Key facts
- Available as
- Kit
- Sold as
- Lymphoseek Kit
- Prescription?
- Prescription only
- Generic available?
- Not in our catalog
How technetium tc-99m tilmanocept is dosed
From the FDA label for Lymphoseek Kit (application NDA202207). Other technetium tc-99m tilmanocept products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.
Lymphoseek is supplied as a kit and must be prepared by radiolabeling with technetium Tc 99m and diluting with the supplied diluent or pharmacy-available sterile 0.9% sodium chloride injection prior to use. ( 2.3 ) • Use aseptic technique and radiation safety precautions during Lymphoseek preparation and handling. Determine the total injection volume and number of sites to be injected for each patient before preparing Lymphoseek. ( 2.1 , 2.3 ) • Recommended dose of Lymphoseek is 18.5 MBq (0.5 mCi) administered at least 15 minutes before initiating intraoperative lymphatic mapping or sentinel node biopsy procedures: complete these procedures within 15 hours of Lymphoseek injection. ( 2.2 , 2.3 ) • Recommended routes of administration are intradermal, subcutaneous, subareolar, or peritumoral. ( 2.3 ) • Use radiolabeled Lymphoseek within 6 hours of its preparation. ( 2.3 ) • See Full Prescribing Information for important preparation and administration instructions. ( 2 ) 2.1 Radiation Safety - Drug Handling Lymphoseek is a radioactive drug and should be handled with appropriate safety measures to decrease radiation exposure [see Warnings and Precautions ( 5.2 )] . Use waterproof gloves, effective radiation shielding, and appropriate safety measures when preparing and handling Lymphoseek. Radiopharmaceuticals should be used by or under the control of physicians who are qualified…
Technetium Tc-99m Tilmanocept side effects
The most common adverse reactions (incidence < 1%) are injection site irritation and/or pain. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Cardinal Health at 1-800-618-2768 or www.lymphoseek.com or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. In open label, single arm clinical trials, 553 adult patients with either breast cancer, melanoma, or squamous cell carcinoma of the oral cavity, skin, and lip received Lymphoseek. No patients experienced serious adverse reactions. Injection site irritation (4 patients; 0.7%) and pain (1 patient; 0.2%) were reported.
Who shouldn’t take technetium tc-99m tilmanocept
None. None. ( 4 )
Every technetium tc-99m tilmanocept product we track (1)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
Only one: Lymphoseek Kit.
What people report to the FDA about technetium tc-99m tilmanocept
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 5 reports naming technetium tc-99m tilmanocept, and the FDA flagged 60% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- erythema2 reports
- abscess1 reports
- arterial haemorrhage1 reports
- cellulitis1 reports
- discomfort1 reports
- drain site complication1 reports
- gram stain positive1 reports
- haemorrhage1 reports
Read these as a signal, not a rate. A report does not mean technetium tc-99m tilmanocept caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label section above.
Source: openFDA drug/event (FAERS), retrieved July 26, 2026.
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Frequently asked questions
What is technetium tc-99m tilmanocept?
Chemical Characteristics The active ingredient in Lymphoseek, a radioactive diagnostic agent, is technetium Tc 99m tilmanocept.
Can you take technetium tc-99m tilmanocept with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run technetium tc-99m tilmanocept against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What forms does technetium tc-99m tilmanocept come in?
Across the brands we track, technetium tc-99m tilmanocept is currently marketed as kit, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic technetium tc-99m tilmanocept?
We do not currently list a generic-labelled technetium tc-99m tilmanocept product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.
Cite this page
- APA
- pharmaranks. (2026, July 24). Technetium Tc-99m Tilmanocept: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/technetium-tc-99m-tilmanocept
- MLA
- “Technetium Tc-99m Tilmanocept: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/technetium-tc-99m-tilmanocept.
We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Read the full FDA label for technetium tc-99m tilmanocept on DailyMed (NIH) ↗.