Technetium Tc-99m Medronate: uses, dosing, side effects & brands
Technetium Tc-99m Medronate is a medicine sold in the U.S. under 2 brand and generic names. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
Key facts
- Available as
- Injectable
- Sold as
- 2 products — Draximage Mdp-10 and Draximage Mdp-25
- Prescription?
- Prescription only
- Generic available?
- Not in our catalog
How technetium tc-99m medronate is dosed
From the FDA label for Draximage Mdp-10 (application NDA018035). Other technetium tc-99m medronate products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.
The recommended adult dose, after reconstitution with oxidant-free sodium pertechnetate Tc-99m, is 370 to 740 megabecquerels (10 to 20 millicuries [200 µCi/kg]) by slow intravenous injection over a period of 30 seconds. Optimum scanning time is 1 to 4 hours post-injection. To minimize the contribution of the bladder content to the image, the patient should void immediately before imaging is started. The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. The solution should not be used if cloudy. RADIATION DOSIMETRY The estimated absorbed radiation doses to an average patient (70 kg) from an intravenous injection of a maximum dose of 740 megabecquerels (20 millicuries) of Technetium Tc 99m Medronate are shown in Table 4. The effective half-life was assumed to be the physical half-life for all calculated values. Table 4 Radiation Doses 2 Tissue Absorbed Radiation Dose mGy/740 MBq rads/20 mCi Total Body Total Bone Red Marrow Kidneys Liver Bladder Wall 2 hr. void 4.8 hr. void Ovaries 2 hr. void 4.8 hr. void Testes 2 hr. void 4.8 hr. void 1.3 7.0 5.6 8.0 0.6 26.0 62.0 2.4 3.4 1.6 2.2 0.13 0.70 0.56 0.80 0.06 2.60 6.20 0.24 0.34 0.16 0.22 2 Method of calculation: “S” Absorbed Dose per Unit Cumulated…
Technetium Tc-99m Medronate side effects
Several cases of allergic dermatological reactions have been reported in association with the use of Technetium Tc 99m Medronate. Several reactions have also been reported in association with other radiopharmaceuticals of the diphosphonate class, particularly Technetium Tc 99m Medronate. These are usually hypersensitivity reactions characterized by itching, various skin rashes, hypotension, chills, nausea, fever, and vomiting. One death secondary to cardiac arrhythmia following the administration of Technetium Tc 99m Medronate has been reported. In addition, one case of cardiac arrest in a patient also undergoing pulmonary function testing one and one-half hours after the performance of a bone scan using Technetium Tc 99m Medronate has been reported.
Who shouldn’t take technetium tc-99m medronate
None known.
Every technetium tc-99m medronate product we track (2)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | Not yet rated | Prescription | Injectable | No data | — | View → | |
| 2 | Not yet rated | Prescription | Injectable | No data | — | View → |
What people report to the FDA about technetium tc-99m medronate
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 47 reports naming technetium tc-99m medronate, and the FDA flagged 19% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- radioisotope uptake increased11 reports
- pruritus6 reports
- urticaria5 reports
- dyspnoea4 reports
- rash4 reports
- erythema3 reports
- eye haemorrhage3 reports
- hypersensitivity3 reports
Read these as a signal, not a rate. A report does not mean technetium tc-99m medronate caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label section above.
Source: openFDA drug/event (FAERS), retrieved July 26, 2026.
Related calculators
Frequently asked questions
What is technetium tc-99m medronate?
DRAXIMAGE® MDP-25 Kit for the Preparation of Technetium Tc 99m Medronate Injection For Intravenous Use DIAGNOSTIC – FOR SKELETAL IMAGING DESCRIPTION The kit consists of reaction vials which contain the sterile, non-pyrogenic,non-radioactive ingredients necessary to produce Technetium Tc 99m Medronate Injection for diagnostic use by intravenous injection. MDP-25 reaction vials are intended to be used as multidose vials. Each 10 mL MDP-25 reaction vial contains 25.0 mg medronic acid and not less than 2.0 mg of stannous chloride dihydrate (maximum total tin expressed as stannous chloride dihydrate 3.0 mg) and 5.0 mg of p-aminobenzoic acid in lyophilized form under an atmosphere of nitrogen. The pH is adjusted to 6.8 to 6.9 with HCI or NaOH prior to lyophilization. The addition of sterile, non-pyrogenic, and oxidant-free sodium pertechnetate Tc-99m sterile solution produces a rapid labeling which is essentially quantitative and which remains stable in vitro throughout the 12-hours life of the preparation. No bacteriostatic preservative is present.
Can you take technetium tc-99m medronate with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run technetium tc-99m medronate against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is technetium tc-99m medronate sold under?
We track 2 technetium tc-99m medronate-containing products in the U.S.: Draximage Mdp-10 and Draximage Mdp-25. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does technetium tc-99m medronate come in?
Across the brands we track, technetium tc-99m medronate is currently marketed as injectable, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic technetium tc-99m medronate?
We do not currently list a generic-labelled technetium tc-99m medronate product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.
Cite this page
- APA
- pharmaranks. (2026, July 24). Technetium Tc-99m Medronate: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/technetium-tc-99m-medronate
- MLA
- “Technetium Tc-99m Medronate: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/technetium-tc-99m-medronate.
We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Read the full FDA label for technetium tc-99m medronate on DailyMed (NIH) ↗.