Prochlorperazine Edisylate: uses, dosing, side effects & brands
Prochlorperazine Edisylate is a phenothiazine sold in the U.S. under one brand, for anxiety disorders, dementia and nausea. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
Key facts
- Drug class
- Phenothiazine
- Treats
- Anxiety Disorders, Dementia and Nausea
- Available as
- Injectable
- Sold as
- Prochlorperazine Edisylate
- Prescription?
- Prescription only
- Generic available?
- Yes
- Boxed warning
- Boxed warning
How prochlorperazine edisylate is dosed
From the FDA label for Prochlorperazine Edisylate (application ANDA214379). Other prochlorperazine edisylate products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.
NOTE ON INJECTION: For intramuscular administration, inject deeply into the upper, outer quadrant of the buttock. Subcutaneous administration is not advisable because of local irritation. Stability This solution should be protected from light. Slight yellowish discoloration will not alter potency. If markedly discolored, solution should be discarded. Compatibility It is recommended that Prochlorperazine Edisylate Injection not be mixed with other agents in the syringe. Adults (For children’s dosage and administration, see below.) Dosage should be increased more gradually in debilitated or emaciated patients. ELDERLY PATIENTS In general, dosages in the lower range are sufficient for most elderly patients. Since they appear to be more susceptible to hypotension and neuromuscular reactions, such patients should be observed closely. Dosage should be tailored to the individual, response carefully monitored, and dosage adjusted accordingly. Dosage should be increased more gradually in elderly patients. TO CONTROL SEVERE NAUSEA AND VOMITING Adjust dosage to the response of the individual. Begin with lowest recommended dosage. IM Dosage Initially 5 mg to 10 mg (1 to 2 mL) injected deeply into the upper, outer quadrant of the buttock. If necessary, repeat every 3 or 4 hours. Total IM dosage should not exceed 40 mg per day. IV Dosage 2.5 mg to 10 mg (0.5 to 2 mL) by slow IV injection or…
Prochlorperazine Edisylate side effects
Drowsiness, dizziness, amenorrhea, blurred vision, skin reactions and hypotension may occur. Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs (see WARNINGS ). Cholestatic jaundice has occurred. If fever with grippe-like symptoms occurs, appropriate liver studies should be conducted. If tests indicate an abnormality, stop treatment. There have been a few observations of fatty changes in the livers of patients who have died while receiving the drug. No causal relationship has been established. Leukopenia and agranulocytosis have occurred. Warn patients to report the sudden appearance of sore throat or other signs of infection. If white blood cell and differential counts indicate leukocyte depression, stop treatment and start antibiotic and other suitable therapy. Neuromuscular (Extrapyramidal) Reactions These symptoms are seen in a significant number of hospitalized mental patients. They may be characterized by motor restlessness, be of the dystonic type, or they may resemble parkinsonism. Depending on the severity of symptoms, dosage should be reduced or discontinued. If therapy is reinstituted, it should be at a lower dosage. Should these symptoms occur in children or pregnant patients, the drug should be stopped and not reinstituted. In most cases barbiturates by suitable route of administration will suffice, or injectable…
Who shouldn’t take prochlorperazine edisylate
Do not use in patients with known hypersensitivity to phenothiazines. Do not use in comatose states or in the presence of large amounts of central nervous system depressants (alcohol, barbiturates, narcotics, etc.). Do not use in pediatric surgery. Do not use in pediatric patients under 2 years of age or under 20 lbs. Do not use in children for conditions for which dosage has not been established.
Every prochlorperazine edisylate product we track (1)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
Only one: Prochlorperazine Edisylate.
How long prochlorperazine edisylate keeps
No prochlorperazine edisylate label we read sets a separate limit for after opening, but they do specify how it must be stored — and the stability behind any date assumes those conditions.
Does prochlorperazine edisylate expire? The in-use limits and storage rules from its labelsWhat people report to the FDA about prochlorperazine edisylate
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 1,720 reports naming prochlorperazine edisylate, and the FDA flagged 74% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- nausea213 reports
- fatigue168 reports
- diarrhoea153 reports
- vomiting121 reports
- asthenia106 reports
- dyspnoea92 reports
- drug hypersensitivity80 reports
- pneumonia77 reports
Read these as a signal, not a rate. A report does not mean prochlorperazine edisylate caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label section above.
Source: openFDA drug/event (FAERS), retrieved July 26, 2026.
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Frequently asked questions
What is prochlorperazine edisylate?
Prochlorperazine Edisylate is a phenothiazine used to treat Anxiety Disorders, Dementia, Nausea, Psychotic Disorders.
What kind of drug is prochlorperazine edisylate?
The FDA classifies prochlorperazine edisylate as a phenothiazine. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.
Can you take prochlorperazine edisylate with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run prochlorperazine edisylate against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What forms does prochlorperazine edisylate come in?
Across the brands we track, prochlorperazine edisylate is currently marketed as injectable, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic prochlorperazine edisylate?
Yes. Our catalog lists 1 generic prochlorperazine edisylate product alongside the brand versions. A generic has the same active ingredient and must meet the FDA's bioequivalence standard; it usually costs less. Ask your pharmacist which one your plan covers.
Cite this page
- APA
- pharmaranks. (2026, July 24). Prochlorperazine Edisylate: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/prochlorperazine-edisylate
- MLA
- “Prochlorperazine Edisylate: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/prochlorperazine-edisylate.
We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Read the full FDA label for prochlorperazine edisylate on DailyMed (NIH) ↗ — including its boxed warning in full.