Linezolid Tablets, USP contain linezolid, which is a synthetic antibacterial agent of the oxazolidinone class. The chemical name for linezolid is (S)-N-[[3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl] methyl]-acetamide. The empirical formula is C 16 H 20 FN 3 O 4 . Its molecular weight is 337.35, and its chemical structure is represented below: Linezolid Tablets, USP for oral administration contains 600 mg linezolid as a film-coated compressed tablet. Inactive ingredients are corn starch, microcrystalline cellulose, silicon dioxide, hydroxypropylcellulose, sodium starch glycolate, magnesium stearate. The coating material contains hypromellose, polyethylene glycol and titanium dioxide. The sodium (Na+) content is 2.52 mg per 600 mg tablet (0.1 mEq/tablet). FDA approved dissolution test specifications differ from USP. 777

What kind of drug is linezolid?

The FDA classifies linezolid as an oxazolidinone antibacterial. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.

Can you take linezolid with other medicines?

It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run linezolid against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.

What brand names is linezolid sold under?

We track 2 linezolid-containing products in the U.S.: Linezolid and Zyvox. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

What forms does linezolid come in?

Across the brands we track, linezolid is currently marketed as powder, injectable, solution, suspension and tablet, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Is there a generic linezolid?

Yes. Our catalog lists 1 generic linezolid product alongside the brand versions. A generic has the same active ingredient and must meet the FDA's bioequivalence standard; it usually costs less. Ask your pharmacist which one your plan covers.

Linezolid: uses, dosing, side effects & brands

Linezolid is an oxazolidinone antibacterial sold in the U.S. under 2 brand and generic names, for staphylococcal infections, streptococcal infections and bacterial skin diseases. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.

By the pharmaranks editorial teamReviewed against the FDA (openFDA label, NDC Directory & Enforcement) sourcesHow we research

Key facts

Drug class: Oxazolidinone Antibacterial
Treats: Staphylococcal Infections, Streptococcal Infections and Bacterial Skin Diseases
Available as: Powder · Injectable · Solution · Suspension · Tablet
Sold as: 2 products — Linezolid and Zyvox
Prescription?: Prescription only
Generic available?: Yes
Typical price: about $1 for a 30-count supply

How linezolid is dosed

From the FDA label for Linezolid (application ANDA210378). Other linezolid products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.

Dosage, Route, and Frequency of Administration Infection Pediatric Patients (Birth through 11 years of Age) Adults and Adolescents (12 years and Older) Duration (days) Nosocomial pneumonia 10 mg/kg oral every 8 hours 600 mg oral every 12 hours 10 to 14 Community-acquired pneumonia, including concurrent bacteremia Complicated skin and skin structure infections Vancomycin-resistant Enterococcus faecium infections, including concurrent bacteremia 10 mg/kg oral every 8 hours 600 mg oral every 12 hours 14 to 28 Uncomplicated skin and skin structure infections less than 5 yrs: 10 mg/kg oral every 8 hours 5-11 yrs: 10 mg/kg oral every 12 hours Adults: 400 mg oral every 12 hours Adolescents: 600 mg oral every 12 hours 10 to 14 2.1 General Dosage and Administration The recommended dosage for linezolid tablets formulations for the treatment of infections is described in Table 1. Table 1. Dosage Guidelines for Linezolid Tablets Infection * Dosage, Route and Frequency of Administration Recommended Duration of Treatment (consecutive days) Pediatric Patients † (Birth through 11 Years of Age) Adults and Adolescents (12 Years and Older) Nosocomial pneumonia 10 mg/kg oral ‡ every 8 hours 600 mg oral ‡ every 12 hours 10 to 14 Community-acquired pneumonia, including concurrent bacteremia Complicated skin and skin structure infections Vancomycin-resistant Enterococcus faecium infections,…

Linezolid side effects

The following clinically significant adverse reactions are described elsewhere in the labeling: • Myelosuppression [see Warnings and Precautions ( 5.1 )] • Peripheral and Optic Neuropathy [see Warnings and Precautions ( 5.2 )] • Serotonin Syndrome [see Warnings and Precautions ( 5.3 )] • Clostridioides difficile-Associated Diarrhea [see Warnings and Precautions ( 5.5 )] • Lactic Acidosis [see Warnings and Precautions ( 5.7 )] • Convulsions [see Warnings and Precautions ( 5.8 )] • Rhabdomyolysis [see Warnings and Precautions ( 5.9 )] • Hypoglycemia [see Warnings and Precautions ( 5.10 )] Hyponatremia and/or Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) [ see Warnings and Precautions ( 5.11 )] Most common adverse reactions (>5% of adult and/or pediatric patients treated with linezolid tablets) include: diarrhea, vomiting, headache, nausea, and anemia. ( 6 ) To report SUSPECTED ADVERSE REACTIONS, contact Macleods Pharma USA, Inc. at 1-888-943-3210 or 1-855-926-3384 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch . 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Adults The safety of linezolid tablets formulations was…

Every linezolid product we track (2)

Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.

Linezolid products
#	Drug	Rating	Type	Form	Generic?	Typical price
1	Linezolid	66/100	Prescription	Suspension	Generic	$1	View →
2	Zyvox	56/100	Prescription	Suspension	Generic

What linezolid pills look like

Imprint codes, colour and shape from the FDA’s labelling data. Match the imprint on your pill — or search any imprint.

Linezolid pill imprints
Imprint	Strength	Colour	Shape	Maker
ZYV;600	600 mg	white	oval	—
LIN600	600 mg	white	capsule	—
ZYV;600	600 mg	white	oval	—

Frequently asked questions

What is linezolid?: Linezolid Tablets, USP contain linezolid, which is a synthetic antibacterial agent of the oxazolidinone class. The chemical name for linezolid is (S)-N-[[3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl] methyl]-acetamide. The empirical formula is C 16 H 20 FN 3 O 4 . Its molecular weight is 337.35, and its chemical structure is represented below: Linezolid Tablets, USP for oral administration contains 600 mg linezolid as a film-coated compressed tablet. Inactive ingredients are corn starch, microcrystalline cellulose, silicon dioxide, hydroxypropylcellulose, sodium starch glycolate, magnesium stearate. The coating material contains hypromellose, polyethylene glycol and titanium dioxide. The sodium (Na+) content is 2.52 mg per 600 mg tablet (0.1 mEq/tablet). FDA approved dissolution test specifications differ from USP. 777
What kind of drug is linezolid?: The FDA classifies linezolid as an oxazolidinone antibacterial. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.
Can you take linezolid with other medicines?: It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run linezolid against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is linezolid sold under?: We track 2 linezolid-containing products in the U.S.: Linezolid and Zyvox. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does linezolid come in?: Across the brands we track, linezolid is currently marketed as powder, injectable, solution, suspension and tablet, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.