Esketamine: uses, dosing, side effects & brands
Esketamine is a medicine sold in the U.S. under one brand. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
Key facts
- Available as
- Solution
- Sold as
- Spravato
- Prescription?
- Prescription only
- Generic available?
- Not in our catalog
Every esketamine product we track (1)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
Only one: Spravato.
Esketamine and breastfeeding
From LactMed, the US National Library of Medicine’s Drugs and Lactation Database — quoted, not rewritten.
Full LactMed record for esketamine: levels in milk, effects in breastfed infants, and the drugs it would consider insteadEsketamine is the more potent S-isomer of the racemic drug, ketamine. Single doses or infusions of intravenous esketamine during or after cesarean section delivery may not affect the breastfed infant and may improve the onset of lactation. Esketamine nasal spray used as an antidepressant has not been studied during breastfeeding. Until more data are available, repeated doses esketamine nasal spray should probably be avoided during breastfeeding.
National Institute of Child Health and Human Development, record revised April 15, 2026. LactMed states its information is not a substitute for professional judgement.
What people report to the FDA about esketamine
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 45 reports naming esketamine, and the FDA flagged 98% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- anaphylactic shock15 reports
- agitation4 reports
- constipation4 reports
- functional gastrointestinal disorder4 reports
- urinary hesitation4 reports
- urinary retention4 reports
- weight increased4 reports
- drug level decreased3 reports
Read these as a signal, not a rate. A report does not mean esketamine caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.
Source: openFDA drug/event (FAERS), retrieved September 25, 2026.
Related calculators
Frequently asked questions
Can you take esketamine with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run esketamine against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What forms does esketamine come in?
Across the brands we track, esketamine is currently marketed as solution, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic esketamine?
We do not currently list a generic-labelled esketamine product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.
Cite this page
- APA
- pharmaranks. (2026, July 24). Esketamine: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/esketamine
- MLA
- “Esketamine: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/esketamine.
We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Read the full FDA label for esketamine on DailyMed (NIH) ↗.