Doxylamine: uses, dosing, side effects & brands
Doxylamine is a medicine sold in the U.S. under 2 brand and generic names. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
Key facts
- Available as
- Tablet · Capsule
- Sold as
- 2 products — Decapryn and Unisom
- Prescription?
- Prescription only
- Generic available?
- Not in our catalog
Can you take doxylamine with…?
Source-cited answers for the combinations people actually ask about — each with a verdict and what to watch for.
Every doxylamine product we track (2)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 70/100 | Prescription | Tablet | No data | — | View → | |
| 2 | 62/100 | Prescription | Capsule | No data | — | View → |
What doxylamine pills look like
Imprint codes, colour and shape from the FDA’s labelling data. Match the imprint on your pill — or search any imprint.
| Imprint | Strength | Colour | Shape | Maker |
|---|---|---|---|---|
| PC10 | 325 mg / 15 mg / 6.25 mg | green | oval | — |
| PC10 | 325 mg / 15 mg / 6.25 mg | green | oval | — |
| PC10 | 325 mg / 15 mg / 6.25 mg | green | capsule | — |
| 71 | 325 mg / 15 mg / 6.25 mg | green | oval | — |
| PC10 | 325 mg / 15 mg / 6.25 mg | green | capsule | — |
| 71 | 325 mg / 15 mg / 6.25 mg | green | oval | — |
| 71 | 15 mg / 6.25 mg / 325 mg | green | oval | — |
| 314;116 | 10 mg / 325 mg / 6.25 mg / 5 mg | green, blue | oval | — |
| G01 | 6.25 mg / 10 mg / 325 mg / 5 mg | green | oval | — |
Combination products containing doxylamine
A combination is a different drug — different dosing, different warnings. It is listed here so you can find it, not so you can substitute it.
How long doxylamine keeps
No doxylamine label we read sets a separate limit for after opening, but they do specify how it must be stored — and the stability behind any date assumes those conditions.
Doxylamine and breastfeeding
From LactMed, the US National Library of Medicine’s Drugs and Lactation Database — quoted, not rewritten.
Full LactMed record for doxylamine: levels in milk, effects in breastfed infants, and the drugs it would consider insteadSmall occasional doses of doxylamine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established.
National Institute of Child Health and Human Development, record revised May 15, 2025. LactMed states its information is not a substitute for professional judgement.
What people report to the FDA about doxylamine
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 3,197 reports naming doxylamine, and the FDA flagged 59% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- somnolence298 reports
- maternal exposure during pregnancy145 reports
- fatigue141 reports
- foetal exposure during pregnancy128 reports
- exposure during pregnancy103 reports
- dizziness95 reports
- nausea95 reports
- diarrhoea87 reports
Read these as a signal, not a rate. A report does not mean doxylamine caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.
Source: openFDA drug/event (FAERS), retrieved August 25, 2026.
Related calculators
Frequently asked questions
Can you take doxylamine with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run doxylamine against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is doxylamine sold under?
We track 2 doxylamine-containing products in the U.S.: Decapryn and Unisom. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does doxylamine come in?
Across the brands we track, doxylamine is currently marketed as tablet and capsule, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic doxylamine?
We do not currently list a generic-labelled doxylamine product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.
What should I avoid while taking doxylamine?
Other medicines: we hold source-cited interaction answers for Can you take Claritin and NyQuil together? and Can you take NyQuil with trazodone?. This is what the FDA label and our cited sources say — it is not a complete list. Your pharmacist can check your own combination.
Cite this page
- APA
- pharmaranks. (2026, July 24). Doxylamine: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/doxylamine
- MLA
- “Doxylamine: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/doxylamine.
We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Read the full FDA label for doxylamine on DailyMed (NIH) ↗.