Diclofenac: uses, dosing, side effects & brands
Diclofenac is a nonsteroidal anti-inflammatory drug sold in the U.S. under 11 brand and generic names, for juvenile arthritis, rheumatoid arthritis and dysmenorrhea. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
Key facts
- Drug class
- Nonsteroidal Anti-Inflammatory Drug
- Treats (across its forms)
- Juvenile Arthritis, Rheumatoid Arthritis and Dysmenorrhea
- Available as
- Topical · Kit · Tablet · Solution · Drops · Tablet, delayed release · Tablet, extended release · Powder · Capsule
- Sold as
- 11 products — Voltaren Arthritis Pain, Cataflam and Diclofenac Sodium, and others
- Prescription?
- Both Rx and OTC forms
- Generic available?
- Yes
- Half-life
- about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)
- What the pharmacy pays
- about $0.36 per ml — not your price
- Boxed warning
- Boxed warning
How Cambia is dosed
From the FDA label for Cambia (application NDA022165). Other diclofenac products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.
Single 50 mg dose; mix single packet contents with 1 to 2 ounces or 2 to 4 tablespoons (30 to 60 mL) of water prior to administration Use the lowest effective dose for shortest duration consistent with individual patient treatment goals ( 2.1 ) 2.1 Acute Treatment of Migraine Administer one packet (50 mg) of Diclofenac Potassium for the acute treatment of migraine. Empty the contents of one packet into a cup containing 1 to 2 ounces or 2 to 4 tablespoons (30 to 60 mL) of water, mix well and drink immediately. Do not use liquids other than water. Taking Diclofenac Potassium with food may cause a reduction in effectiveness compared to taking Diclofenac Potassium on an empty stomach [ see Clinical Pharmacology ( 12.3 ) ]. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. The safety and effectiveness of a second dose have not been established. 2.2 Non-Interchangeability with Other Formulations of Diclofenac Different formulations of oral diclofenac (e.g.,Diclofenac Potassium, diclofenac sodium enteric-coated tablets, diclofenac sodium extended-release tablets, or diclofenac potassium immediate-release tablets) may not be bioequivalent even if the milligram strength is the same. Therefore, it is not possible to convert dosing from any other formulation of diclofenac to Diclofenac Potassium. 2.1 Acute Treatment of Migraine…
Everything below is the FDA label for Cambia (powder). Diclofenac is also sold as topical, kit, tablet, solution, drops, tablet, delayed release, tablet, extended release and capsule, and those are different medicines to take — follow the label for the one you were prescribed.
Cambia side effects
The following serious adverse reactions are discussed in greater detail in other sections of the labeling: Cardiovascular Thrombotic Events [ see Warnings and Precautions ( 5.1 ) ] GI Bleeding, Ulceration and Perforation [ see Warnings and Precautions ( 5.2 ) ] Hepatotoxicity [ see Warnings and Precautions ( 5.3 ) ] Hypertension [ see Warnings and Precautions ( 5.4 ) ] Heart Failure and Edema [ see Warnings and Precautions ( 5.5 ) ] Renal Toxicity and Hyperkalemia [ see Warnings and Precautions ( 5.6 ) ] Anaphylactic Reactions [ see Warnings and Precautions ( 5.7 ) ] Serious Skin Reactions [ see Warnings and Precautions ( 5.9 ) ] Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) [ see Warnings and Precautions (5.10) ] Medication Overuse Headache [ see Warnings and Precautions (5.11) ] Hematologic Toxicity [ see Warnings and Precautions ( 5.13 ) ] Most common adverse reactions (≥1% and >placebo) were nausea and dizziness ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Leading Pharma, LLC at 1-844-740-7500 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice. The safety of…
Who shouldn’t take Cambia
Diclofenac Potassium is contraindicated in the following patients: Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to diclofenac or any components of the drug product [ see Warnings and Precautions ( 5.7 , 5.9 ) ] History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients [see Warnings and Precautions ( 5.7 , 5.8 ) ] In the setting of coronary artery bypass graft (CABG) surgery [see Warnings and Precautions ( 5.1 ) ] Known hypersensitivity to diclofenac or NSAIDs or any components of the drug product ( 4 ) History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs ( 4 ) In the setting of (CABG) surgery ( 4 )
Cambia drug interactions
See Table 2 for clinically significant drug interactions with diclofenac. Table 2: Clinically Significant Drug Interactions with Diclofenac Drugs That Interfere with Hemostasis Clinical Impact: Diclofenac and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of diclofenac and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone. Serotonin release by platelets plays an important role in hemostasis. Case- control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone. Intervention: Monitor patients with concomitant use of Diclofenac Potassium with anticoagulants (e.g., warfarin), antiplatelet agents (e.g., aspirin), selective serotonin reuptake inhibitors (SSRIs), and serotonin norepinephrine reuptake inhibitors (SNRIs) for signs of bleeding [ see Warnings and Precautions ( 5.13 ) ] Aspirin Clinical Impact: Controlled clinical studies showed that the concomitant use of NSAIDs and analgesic doses of aspirin does not produce any greater therapeutic effect than the use of NSAIDs alone. In a clinical study, the concomitant use of an NSAID and aspirin was associated with a significantly increased incidence of GI adverse reactions as compared to use of the NSAID alone [ see Warnings and Precautions ( 5.2 ) and Clinical Pharmacology ( 12.3 ) ]. Intervention: Concomitant use of Diclofenac Potassium and analgesic doses of aspirin is not generally recommended because of the increased risk of bleeding [ see Warnings and Precautions ( 5.13 ) ]. ACE Inhibitors, Angiotensin Receptor Blockers, and Beta-blockers Clinical Impact: NSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta- blockers (including propranolol). In patients who are elderly, volume-depleted (including those on diuretic therapy), or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Intervention: During concomitant use of Diclofenac Potassium and ACE-inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. During concomitant use of Diclofenac Potassium and ACE-inhibitors or ARBs in patients who are elderly, volume-depleted, or have impaired renal function, monitor for signs of worsening renal function [ see Warnings and Precautions ( 5.6 ) ]. Diuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. This effect has been attributed to the NSAID inhibition of renal prostaglandin synthesis. Intervention: During concomitant use of Diclofenac Potassium with diuretics, observe patients for signs of worsening renal function, in addition to assuring diuretic efficacy including antihypertensive effects [ see Warnings and Precautions ( 5.6 ) ]. Digoxin Clinical Impact: The concomitant use of diclofenac with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. Intervention: During concomitant use of Diclofenac Potassium and digoxin, monitor serum digoxin levels. Lithium Clinical Impact: NSAIDs have produced elevations in plasma lithium levels and reductions in renal lithium clearance. The mean minimum lithium concentration increased 15%, and the renal clearance decreased by approximately 20%. This effect has been attributed to NSAID inhibition of renal prostaglandin synthesis. Intervention: During concomitant use of Diclofenac Potassium and lithium, monitor patients for signs of lithium toxicity. Methotrexate Clinical Impact: Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction). Intervention: During concomitant use of Diclofenac Potassium and methotrexate, monitor patients for methotrexate toxicity. Cyclosporine Clinical Impact: Concomitant use of Diclofenac Potassium and cyclosporine may increase cyclosporine’s nephrotoxicity. Intervention: During concomitant use of Diclofenac Potassium and cyclosporine, monitor patients for signs of worsening renal function. NSAIDs and Salicylates Clinical Impact: Concomitant use of diclofenac with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of GI toxicity, with little or no increase in efficacy [ see Warnings and Precautions ( 5.2 ) ]. Intervention: The concomitant use of diclofenac with other NSAIDs or salicylates is not recommended. Pemetrexed Clinical Impact: Concomitant use of Diclofenac Potassium and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity (see the pemetrexed prescribing information). Intervention: During concomitant use of NSAIDs and pemetrexed, in patients with renal impairment whose creatinine clearance ranges from 45 to 79 mL/min, monitor for myelosuppression, renal and GI toxicity. NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed. In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives (e.g., meloxicam, nabumetone), patients taking these NSAIDs should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration. Inhibitors of Cytochrome P450 2C9 Clinical Impact: Diclofenac is metabolized predominantly by Cytochrome P-450 CYP2C9. Co- administration of medications that inhibit CYP2C9 may affect the pharmacokinetics of diclofenac [ see Clinical Pharmacology ( 12.3 ) ] Intervention: During concomitant use of Diclofenac Potassium and drugs that inhibit CYP2C9, an increase in the duration between Diclofenac Potassium doses for subsequent migraine attacks may be necessary. Drugs that Interfere with Hemostasis (e.g. warfarin, aspirin, SSRIs/SNRIs): Monitor patients for bleeding who are concomitantly taking Diclofenac Potassium with drugs that interfere with hemostasis. Concomitant use of Diclofenac Potassium and analgesic doses of aspirin is not generally recommended ( 7 ) ACE Inhibitors and ARBs: Concomitant use with Diclofenac Potassium in elderly, volume depleted, or those with renal impairment may result in deterioration of renal function. In such high risk patients, monitor for signs of worsening renal function ( 7 ) Diuretics: NSAIDs can reduce natriuretic effect of loop and thiazide diuretics. Monitor patients to assure diuretic efficacy including antihypertensive effects ( 7 ) Digoxin: Concomitant use with Diclofenac Potassium can increase serum concentration and prolong half-life of digoxin. Monitor serum digoxin levels ( 7 )
Every diclofenac product we track (11)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 72/100 | Over-the-counter | Topical | Generic | $0 | View → | |
| 2 | 70/100 | Prescription | Tablet | Generic | $0 | View → | |
| 3 | 70/100 | Prescription | Solution | Generic | $0 | View → | |
| 4 | 70/100 | Prescription | Tablet | Generic | $0 | View → | |
| 5 | 70/100 | Prescription | Tablet | Generic | $0 | View → | |
| 6 | Not yet rated | Prescription | Solution | Generic | $0 | View → | |
| 7 | Not yet rated | Prescription | Capsule | Generic | $0 | View → | |
| 8 | Not yet rated | Prescription | Solution | Generic | $0 | View → | |
| 9 | Not yet rated | Prescription | Solution | Generic | $0 | View → | |
| 10 | Not yet rated | Prescription | Capsule | Generic | $0 | View → |
What diclofenac pills look like
Imprint codes, colour and shape from the FDA’s labelling data. Match the imprint on your pill — or search any imprint.
| Imprint | Strength | Colour | Shape | Maker |
|---|---|---|---|---|
| P;75 | 75 mg | brown | round | — |
| R;550 | 50 mg | white | round | — |
| R;551 | 75 mg | white | round | — |
| ING;278 | 100 mg | pink | round | — |
| UpArrowheadE11 | 50 mg | white | round | — |
| I;279 | 50 mg | white | round | — |
| UpArrowheadE11 | 50 mg | white | round | — |
| I;279 | 50 mg | white | round | — |
Combination products containing diclofenac
A combination is a different drug — different dosing, different warnings. It is listed here so you can find it, not so you can substitute it.
Diclofenac recalls
From the FDA Enforcement database. A recall covers specific lots — not the drug as a whole.
How long diclofenac keeps
No diclofenac label we read sets a separate limit for after opening, but they do specify how it must be stored — and the stability behind any date assumes those conditions.
Does diclofenac expire? The in-use limits and storage rules from its labelsDiclofenac and breastfeeding
From LactMed, the US National Library of Medicine’s Drugs and Lactation Database — quoted, not rewritten.
Full LactMed record for diclofenac: levels in milk, effects in breastfed infants, and the drugs it would consider insteadData on excretion of diclofenac into milk are poor, but the drug has a short half-life and little glucuronide metabolite formation. Levels in milk appear to be quite low. Most reviewers consider diclofenac to be acceptable during breastfeeding. Other agents having more published information may be preferred, especially while nursing a newborn or preterm infant.
National Institute of Child Health and Human Development, record revised July 15, 2026. LactMed states its information is not a substitute for professional judgement.
What people report to the FDA about diclofenac
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 99,855 reports naming diclofenac, and the FDA flagged 79% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- fatigue12,711 reports
- rheumatoid arthritis10,221 reports
- arthralgia9,960 reports
- rash9,852 reports
- abdominal discomfort9,333 reports
- alopecia8,680 reports
- joint swelling8,556 reports
- systemic lupus erythematosus8,389 reports
Read these as a signal, not a rate. A report does not mean diclofenac caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label section above.
Source: openFDA drug/event (FAERS), retrieved August 25, 2026.
How long diclofenac stays in your system
The elimination half-life of diclofenac is about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation). This is the terminal (elimination) half-life of unchanged diclofenac, as the label labels it — "Terminal Half-life (hr) 2.3" in the PK table, and in the text "the terminal half-life of unchanged diclofenac is approximately 2 hours." Diclofenac is not a prodrug, and it has no active metabolite that outlasts it: the label names five metabolites and says the major one, 4'-hydroxy-diclofenac, has "very weak pharmacologic activity," so the parent's ~2-hour half-life is what governs. (The related diclofenac/misoprostol label notes one additional urinary metabolite with an 80-hour half-life, but it accounts for only ~1.4% of the dose.) Populations the label names: kidney impairment — no dose adjustment for mild-to-moderate impairment; in subjects with inulin clearance 60-90, 30-60 and <30 mL/min, AUC and elimination rate were comparable to healthy subjects. Liver impairment — hepatic metabolism accounts for almost 100% of diclofenac elimination, so patients with liver disease may need reduced doses; the label does not give a revised half-life number. This label reports no pharmacokinetic study in older adults or in children; the diclofenac/misoprostol label found no PK differences in subjects aged 66-81 versus younger adults. Half-life describes how the drug leaves plasma. It is not a detection window (metabolites are detectable far longer) and not dosing guidance.
DailyMed — DICLOFENAC SODIUM tablet, delayed release (FDA label, Clinical Pharmacology / Pharmacokinetics) ↗Half-life is how long the body takes to clear half a dose. It is not the same as how long a drug test can detect it, and it varies with age, kidney and liver function.
Related calculators
Frequently asked questions
What is Cambia?
Diclofenac Potassium powder for oral solution is a nonsteroidal anti-inflammatory drug, available as a buffered soluble powder, designed to be mixed with water prior to oral administration. Diclofenac Potassium is a white to off-white, buffered, flavored powder for oral solution packaged in individual unit dose packets.
What kind of drug is diclofenac?
The FDA classifies diclofenac as a nonsteroidal anti-inflammatory drug. NSAIDs block cyclooxygenase (COX) enzymes that your body uses to make prostaglandins, the chemicals behind pain, swelling, and fever. Lowering prostaglandins eases pain and inflammation and brings down a high temperature. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.
How long does diclofenac stay in your system?
The elimination half-life of diclofenac is about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation) — that is how long the body takes to clear half of a dose. This is the terminal (elimination) half-life of unchanged diclofenac, as the label labels it — "Terminal Half-life (hr) 2.3" in the PK table, and in the text "the terminal half-life of unchanged diclofenac is approximately 2 hours." Diclofenac is not a prodrug, and it has no active metabolite that outlasts it: the label names five metabolites and says the major one, 4'-hydroxy-diclofenac, has "very weak pharmacologic activity," so the parent's ~2-hour half-life is what governs. (The related diclofenac/misoprostol label notes one additional urinary metabolite with an 80-hour half-life, but it accounts for only ~1.4% of the dose.) Populations the label names: kidney impairment — no dose adjustment for mild-to-moderate impairment; in subjects with inulin clearance 60-90, 30-60 and <30 mL/min, AUC and elimination rate were comparable to healthy subjects. Liver impairment — hepatic metabolism accounts for almost 100% of diclofenac elimination, so patients with liver disease may need reduced doses; the label does not give a revised half-life number. This label reports no pharmacokinetic study in older adults or in children; the diclofenac/misoprostol label found no PK differences in subjects aged 66-81 versus younger adults. Half-life describes how the drug leaves plasma. It is not a detection window (metabolites are detectable far longer) and not dosing guidance. Half-life is not the same as how long a drug test can detect the drug, and it varies with age, kidney and liver function.
Can you take diclofenac with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run diclofenac against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is diclofenac sold under?
We track 11 diclofenac-containing products in the U.S.: Voltaren Arthritis Pain, Cataflam, Diclofenac Sodium, Voltaren, Voltaren-XR, Cambia, Diclofenac Potassium and Dyloject, and 3 more. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does diclofenac come in?
Across the brands we track, diclofenac is currently marketed as topical, kit, tablet, solution, drops, tablet, delayed release, tablet, extended release, powder and capsule, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic diclofenac?
Yes. Our catalog lists 2 generic diclofenac products alongside the brand versions. A generic has the same active ingredient and must meet the FDA's bioequivalence standard; it usually costs less. Ask your pharmacist which one your plan covers.
Has diclofenac been recalled?
The FDA's Enforcement database lists 2 recall records whose product description mentions diclofenac. The most recent: Diclofenac Sodium (Jan 27, 2026). A recall applies to specific lots, not to the drug as a whole — check the record for the affected lot numbers.
Cite this page
- APA
- pharmaranks. (2026, July 24). Diclofenac: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/diclofenac
- MLA
- “Diclofenac: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/diclofenac.
We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Read the full FDA label for diclofenac on DailyMed (NIH) ↗ — including its boxed warning in full.