Clobetasol: uses, dosing, side effects & brands
Clobetasol is a corticosteroid sold in the U.S. under 9 brand and generic names, for dermatitis, facial dermatoses and foot dermatoses. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
Key facts
- Drug class
- Corticosteroid
- Treats (across its forms)
- Dermatitis, Facial Dermatoses and Foot Dermatoses
- Available as
- Topical · Solution · Spray/Inhaler · Drops
- Sold as
- 9 products — Impoyz, Byqlovi and Temovate, and others
- Prescription?
- Prescription only
- Generic available?
- Yes
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How Impoyz is dosed
From the FDA label for Impoyz (application NDA209483). Other clobetasol products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.
Apply a thin layer of Clobetasol Propionate Cream to the affected skin areas twice daily and rub in gently and completely. Wash hands after each application. Use Clobetasol Propionate Cream for up to 2 consecutive weeks of treatment. (2) • Discontinue Clobetasol Propionate Cream when control is achieved. (2) • The total dosage should not exceed 50 g per week. (2) • Do not use if atrophy is present at the treatment site. (2) • Do not bandage, cover, or wrap the treated skin area unless directed by a physician. (2) • Avoid use on the face, scalp, axilla, groin, or other intertriginous areas. (2) • Clobetasol Propionate Cream is for topical use only. It is not for oral, ophthalmic, or intravaginal use. (2)
Everything below is the FDA label for Impoyz (topical). Clobetasol is also sold as solution, spray/inhaler and drops, and those are different medicines to take — follow the label for the one you were prescribed.
Impoyz side effects
The most common adverse reaction (incidence ≥ 1%) is application site discoloration. (6.1) To report SUSPECTED ADVERSE REACTIONS, contact INA Pharmaceutics, Inc. at 1-866-835-0469 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Clobetasol Propionate Cream was evaluated in two randomized, multicenter, prospective, vehicle-controlled clinical trials in subjects with moderate to severe plaque psoriasis. Subjects applied Clobetasol Propionate Cream or vehicle cream twice daily for 14 days. A total of 354 subjects applied Clobetasol Propionate Cream and 178 subjects applied vehicle. The adverse reaction that occurred in at least 1% of subjects treated with Clobetasol Propionate Cream and at a higher incidence than in subjects treated with vehicle cream was application site discoloration (2% versus 1%). Less common local adverse events occurring in < 1% of subjects treated with Clobetasol Propionate Cream were application site atrophy, telangiectasia and rash. 6.2 Postmarketing Experience The following adverse reactions have been identified during post-approval use of clobetasol propionate:…
Who shouldn’t take Impoyz
None. None ( 4 )
Every clobetasol product we track (9)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 72/100 | Prescription | Topical | No data | — | View → | |
| 2 | 70/100 | Prescription | Suspension | No data | — | View → | |
| 3 | 70/100 | Prescription | Topical | No data | — | View → | |
| 4 | 70/100 | Prescription | Topical | No data | — | View → | |
| 5 | Not yet rated | Prescription | Topical | No data | — | View → | |
| 6 | Not yet rated | Prescription | Spray/Inhaler | No data | — | View → | |
| 7 | Not yet rated | Prescription | Topical | No data | — | View → | |
| 8 | Not yet rated | Prescription | Topical | No data | — | View → | |
| 9 | Not yet rated | Prescription | Topical | No data | — | View → |
Can you crush or split clobetasol?
At least one clobetasolproduct is labelled to be swallowed whole — crushing an extended-release tablet releases the whole day’s dose at once. Which applies depends on the form you were given.
What each clobetasol label says about crushing, splitting and chewingClobetasol and breastfeeding
From LactMed, the US National Library of Medicine’s Drugs and Lactation Database — quoted, not rewritten.
Full LactMed record for clobetasol: levels in milk, effects in breastfed infants, and the drugs it would consider insteadClobetasol has not been studied during breastfeeding. Since only extensive application of the most potent corticosteroids may cause systemic effects in the mother, it is unlikely that short-term application of topical corticosteroids would pose a risk to the breastfed infant by passage into breastmilk. However, it would be prudent to use the least potent drug on the smallest area of skin possible. It is particularly important to ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only the lower potency corticosteroids should be used on the nipple or areola where the infant could directly ingest the drugs from the skin; clobetasol should be avoided on the nipple. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking. Any topical corticosteroid should be wiped off thoroughly prior to nursing if it is being applied to the breast or nipple area.
National Institute of Child Health and Human Development, record revised January 18, 2021. LactMed states its information is not a substitute for professional judgement.
What people report to the FDA about clobetasol
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 11,027 reports naming clobetasol, and the FDA flagged 48% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- pruritus908 reports
- rash658 reports
- psoriasis578 reports
- fatigue522 reports
- headache521 reports
- nausea456 reports
- diarrhoea436 reports
- arthralgia416 reports
Read these as a signal, not a rate. A report does not mean clobetasol caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label section above.
Source: openFDA drug/event (FAERS), retrieved July 25, 2026.
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Frequently asked questions
What is Impoyz?
Impoyz (Clobetasol Propionate) is a corticosteroid used to treat Dermatitis, Facial Dermatoses, Foot Dermatoses, Hand Dermatoses.
What kind of drug is clobetasol?
The FDA classifies clobetasol as a corticosteroid. Corticosteroids mimic the body's natural stress hormone cortisol: they enter cells and bind a glucocorticoid receptor that switches off genes for inflammatory chemicals, calming swelling, redness, and an overactive immune response. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.
Can you take clobetasol with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run clobetasol against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is clobetasol sold under?
We track 9 clobetasol-containing products in the U.S.: Impoyz, Byqlovi, Temovate, Temovate E, Clobetasol Propionate, Clobex, Impeklo and Olux, and 1 more. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
What forms does clobetasol come in?
Across the brands we track, clobetasol is currently marketed as topical, solution, spray/inhaler and drops, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic clobetasol?
Yes. Our catalog lists 1 generic clobetasol product alongside the brand versions. A generic has the same active ingredient and must meet the FDA's bioequivalence standard; it usually costs less. Ask your pharmacist which one your plan covers.
Cite this page
- APA
- pharmaranks. (2026, July 24). Clobetasol: uses, dosing, side effects & brands. https://pharmaranks.com/drugs/clobetasol
- MLA
- “Clobetasol: uses, dosing, side effects & brands.” pharmaranks, 24 July 2026, https://pharmaranks.com/drugs/clobetasol.
We summarise public FDA and NIH sources — for a clinical claim, cite the primary source we link to as well.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Read the full FDA label for clobetasol on DailyMed (NIH) ↗.