Cefotetan Disodium — uses, dosing, side effects & the brands that sell it · pharmaranks
Cefotetan Disodium: uses, dosing, side effects & brands
Cefotetan Disodium is a cephalosporin antibacterial sold in the U.S. under 3 brand and generic names, for abscess, bacteroides infections and human bites. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.
By the pharmaranks editorial team·Reviewed against the FDA (openFDA label, NDC Directory & Enforcement) sources·How we research
Key facts
Drug class
Cephalosporin Antibacterial
Treats
Abscess, Bacteroides Infections and Human Bites
Available as
Injectable
Sold as
3 products — Cefotan, Cefotan in Plastic Container and Cefotetan and Dextrose in Duplex Container
Prescription?
Prescription only
Generic available?
Not in our catalog
How cefotetan disodium is dosed
From the FDA label for Cefotan (application NDA050588). Other cefotetan disodium products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.
Treatment The usual adult dosage is 1 gram (g) or 2 grams of CEFOTAN® (Cefotetan for Injection, USP) administered intravenously or intramuscularly. Proper dosage and route of administration should be determined by the condition of the patient, severity of the infection, and susceptibility of the causative organism. General Guidelines for Dosage of CEFOTAN ® (Cefotetan for Injection, USP) Type of Infection Daily Dose Frequency and Route Urinary Tract 1 g to 4 g 500 mg every 12 hours intravenous or intramuscular 1 or 2 g every 24 hours intravenous or intramuscular 1 or 2 g every 12 hours intravenous or intramuscular Skin & Skin Structure Mild - Moderate a 2 g 2 g every 24 hours intravenous 1 g every 12 hours intravenous or intramuscular Severe 4 g 2 g every 12 hours intravenous Other Sites 2 g to 4 g 1 g or 2 g every 12 hours intravenous or intramuscular Severe 4 g 2 g every 12 hours intravenous Life-Threatening 6 g b 3 g every 12 hours intravenous General Guidelines for Dosage of CEFOTAN ® (Cefotetan for Injection, USP) Type of Infection Daily Dose Frequency and Route Urinary Tract 1 to 4 grams 500 mg every 12 hours IV or IM 1 or 2 g every 24 hours IV or IM 1 or 2 g every 12 hours IV or IM Skin & Skin Structure Mild - Moderate a Severe 2 grams 2 g every 24 hours IV 1 g every 12 hours IV or IM 4 grams 2 g every 12 hours IV Other Sites 2 to 4 grams 1 or 2 g every 12 hours IV or…
Cefotetan Disodium side effects
In clinical studies, the following adverse effects were considered related to CEFOTAN therapy. Those appearing in italics have been reported during postmarketing experience. Gastrointestinal: symptoms occurred in 1.5% of patients, the most frequent were diarrhea (1 in 80) and nausea (1 in 700); pseudomembranous colitis . Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment or surgical prophylaxis (see WARNINGS ). Hematologic: laboratory abnormalities occurred in 1.4% of patients and included eosinophilia (1 in 200), positive direct Coombs test (1 in 250), and thrombocytosis (1 in 300); agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia, and prolonged prothrombin time with or without bleeding . Hepatic: enzyme elevations occurred in 1.2% of patients and included a rise in ALT (SGPT) (1 in 150), AST (SGOT) (1 in 300), alkaline phosphatase (1 in 700), and LDH (1 in 700). Hypersensitivity: reactions were reported in 1.2% of patients and included rash (1 in 150) and itching (1 in 700); anaphylactic reactions and urticaria . Local: effects were reported in less than 1% of patients and included phlebitis at the site of injection (1 in 300), and discomfort (1 in 500). Renal: Elevations in BUN and serum creatinine have been reported . Urogenital: Nephrotoxicity has rarely been reported . Miscellaneous: Fever In addition to the adverse…
Every cefotetan disodium product we track (3)
Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.
CEFOTAN ® (Cefotetan for Injection, USP), as cefotetan disodium, is a sterile, semisynthetic, broad-spectrum, beta-lactamase resistant, cephalosporin (cephamycin) antibiotic for parenteral administration. It is the disodium salt of [6 R -(6α,7α)]-7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]amino]-7-methoxy-3-[[(1-methyl-1 H -tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. Structural formula: CEFOTAN ® (Cefotetan for Injection, USP) is supplied in vials containing 80 mg (3.5 mEq) of sodium per gram of cefotetan activity. It is a white to pale yellow powder which is very soluble in water. Reconstituted solutions of CEFOTAN ® (cefotetan for Injection, USP) are intended for intravenous and intramuscular administration. The solution varies from colorless to yellow depending on the concentration. The pH of freshly reconstituted solutions is usually between 4.5 to 6.5. CEFOTAN ® (Cefotetan for Injection, USP) is available in two vial strengths. Each 1 gram vial contains cefotetan disodium equivalent to 1 gram cefotetan activity. Each 2 gram vial contains cefotetan disodium equivalent to 2 grams cefotetan activity. Cefotetan Chemical Structure
What kind of drug is cefotetan disodium?
The FDA classifies cefotetan disodium as a cephalosporin antibacterial. Cephalosporins kill bacteria by blocking the proteins they use to build their cell walls. Without an intact wall, the bacterium cannot hold its shape and dies, which clears the infection. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.
Can you take cefotetan disodium with other medicines?
It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run cefotetan disodium against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is cefotetan disodium sold under?
We track 3 cefotetan disodium-containing products in the U.S.: Cefotan, Cefotan in Plastic Container and Cefotetan and Dextrose in Duplex Container. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.
Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.
Who shouldn’t take cefotetan disodium
CEFOTAN® is contraindicated in patients with a known allergy to the cephalosporin group of antibiotics and in those individuals who have experienced a cephalosporin associated hemolytic anemia.
Across the brands we track, cefotetan disodium is currently marketed as injectable, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.
Is there a generic cefotetan disodium?
We do not currently list a generic-labelled cefotetan disodium product. That does not always mean none exists — it means none appears under a generic name in the FDA data we track. Ask your pharmacist.