Can you crush or split diltiazem?
The answer belongs to the form, not the drug name. An extended-release tablet meters the dose out over hours; crushing it delivers the whole day at once. Match the product below to the one on your box — if yours is not listed, read its own label.
What each label says
Swallow whole — the label says not to crush or chew it
“Patients should be cautioned that the diltiazem hydrochloride extended-release capsules should not be opened, chewed or crushed, and should be swallowed whole.”
On the label for Diltiazem Hydrochloride · DailyMed
Swallow whole — the label says not to crush or chew it
“Diltiazem Hydrochloride tablets may be swallowed whole, crushed, or chewed.”
On the label for Diltiazem Hydrochloride · DailyMed
Swallow whole — the label says not to crush or chew it
“Do not split Diltiazem Hydrochloride tablets.”
On the label for Diltiazem Hydrochloride · DailyMed
Swallow whole — the label says not to crush or chew it
“Diltiazem tablets may be swallowed whole, crushed, or chewed.”
On the label for Diltiazem Hydrochloride · DailyMed
Swallow whole — the label says not to crush or chew it
“Do not split diltiazem tablets.”
On the label for Diltiazem Hydrochloride · DailyMed
Swallow whole — the label says not to crush or chew it
“Information for Patients 30 mg – Diltiazem tablets may be swallowed whole, crushed, or chewed.”
On the label for Diltiazem Hydrochloride · DailyMed
Swallow whole — the label says not to crush or chew it
“Do not chew or crush the tablet.”
On the label for DILTIAZEM HYDROCHLORIDE · DailyMed
Swallow whole — the label says not to crush or chew it
“Tablet should be swallowed whole and not chewed or crushed.”
On the label for DILTIAZEM HYDROCHLORIDE · DailyMed
Swallow whole — the label says not to crush or chew it
“Advise patients: That the diltiazem hydrochloride extended-release tablets should be swallowed whole and not chewed or crushed.”
On the label for DILTIAZEM HYDROCHLORIDE · DailyMed
Swallow whole — the label says not to crush or chew it
“DILT-XR [Diltiazem Hydrochloride Extended-Release Capsules, USP (Once-a-day dosage)] should not be opened, chewed or crushed, and should be swallowed whole.”
On the label for DILTIAZEM HYDROCHLORIDE · DailyMed
Swallow whole — the label says not to crush or chew it
“Diltiazem Hydrochloride Extended-Release Capsules, USP (Once-a-day dosage) should not be opened, chewed or crushed, and should be swallowed whole.”
On the label for DILTIAZEM HYDROCHLORIDE · DailyMed
Swallow whole — the label says not to crush or chew it
“Advise patients: • That the CARDIZEM LA tablet should be swallowed whole and not chewed or crushed.”
On the label for Cardizem LA · DailyMed
Frequently asked questions
Can you crush diltiazem?
It depends on which diltiazem product you have, which is why this page quotes each label separately rather than answering for the drug name. At least one form is labelled to be swallowed whole — crushing an extended-release tablet releases the whole day's dose at once, which is the reason those instructions exist.
Why does it depend on the form and not the drug?
Because the restriction is built into the tablet, not the molecule. Extended-release and enteric-coated tablets carry a coating or matrix that meters the dose out over hours; crushing destroys it and delivers everything immediately. The same drug in an immediate-release tablet often has no such restriction, which is why a list of drug names cannot answer this question and a quoted label can.
What if I can't swallow the tablet?
Ask the prescriber or pharmacist rather than crushing it anyway — most drugs that cannot be crushed exist in another form (liquid, dispersible tablet, patch, or an immediate-release version taken more often) and switching is usually straightforward. Some labels explicitly describe an alternative, and where they do it is quoted above.
More on diltiazem
Quoted from FDA labels for reference, not medical advice. Never crush or split a tablet against its label to make it easier to take — ask the prescriber or pharmacist, because an alternative form usually exists.