Best treatments for xerostomia
9 products may treat xerostomia, spanning FDA drug classes such as ergotamine derivative, cholinergic receptor agonist. The current highest-rated option is brekiya (autoinjector). Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.
Quick answer: Of the 9 drugs we list for xerostomia, all are available as lower-cost generics, spanning classes such as ergotamine derivative, cholinergic receptor agonist. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for xerostomia — so confirm the right choice with your prescriber.
Top-rated picks for xerostomia: 1. Brekiya (Autoinjector) · 2. Isopto Carpine · 3. Atzumi
| # | Drug | Rating | Type | Form | Class | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|---|
| 1 | 70/100 | Prescription | Injectable | Ergotamine Derivative | Generic | $35 | View → | |
| 2 | 68/100 | Prescription | Drops | Cholinergic Receptor Agonist | Generic | $0 | View → | |
| 3 | Not yet rated | Prescription | Powder | Ergotamine Derivative | Generic | $35 | View → | |
| 4 | Not yet rated | Prescription | Injectable | Ergotamine Derivative | Generic | $35 | View → | |
| 5 | Not yet rated | Prescription | Spray/Inhaler | Ergotamine Derivative | Generic | $35 | View → | |
| 6 | Not yet rated | Prescription | Drops | Cholinergic Receptor Agonist | Generic | $0 | View → | |
| 7 | Not yet rated | Prescription | Solution | Cholinergic Receptor Agonist | Generic | $0 | View → | |
| 8 | Not yet rated | Prescription | Tablet | Cholinergic Receptor Agonist | Generic | $0 | View → | |
| 9 | Not yet rated | Prescription | Spray/Inhaler | Ergotamine Derivative | Generic | $35 | View → |
Narrow by drug class
Explore the class hubs: ergotamine derivative · cholinergic receptor agonist
Full ranking · 9 treatments
brekiya (autoinjector)
Boxed warningPrescriptionFDA-sourced
Brekiya (Autoinjector) (Dihydroergotamine Mesylate) is an ergotamine derivative used to treat Cluster Headache, Postpartum Hemorrhage, Orthostatic Hypotension, Migraine Disorders.
Pharmacy pays
From ~$33.73· 2 forms
isopto carpine
PrescriptionFDA-sourced
Isopto Carpine (Pilocarpine Hydrochloride) is a cholinergic receptor agonist used to treat Head and Neck Neoplasms, Xerostomia, Angle-Closure Glaucoma, Mydriasis.
Pharmacy pays
From ~$0.33· 6 formsatzumi
Boxed warningPrescriptionFDA-sourced
Atzumi (Dihydroergotamine Mesylate) is an ergotamine derivative used to treat Cluster Headache, Postpartum Hemorrhage, Orthostatic Hypotension, Migraine Disorders.
Pharmacy pays
From ~$33.73· 2 formsdihydroergotamine mesylate
Boxed warningPrescriptionFDA-sourced
Dihydroergotamine Mesylate is an ergotamine derivative used to treat Cluster Headache, Postpartum Hemorrhage, Orthostatic Hypotension, Migraine Disorders.
Pharmacy pays
From ~$33.73· 2 formsmigranal
Boxed warningPrescriptionFDA-sourced
Migranal (Dihydroergotamine Mesylate) is an ergotamine derivative used to treat Cluster Headache, Postpartum Hemorrhage, Orthostatic Hypotension, Migraine Disorders.
Pharmacy pays
From ~$33.73· 2 formspilocarpine hydrochloride
PrescriptionFDA-sourced
Pilocarpine Hydrochloride is a cholinergic receptor agonist used to treat Head and Neck Neoplasms, Xerostomia, Angle-Closure Glaucoma, Mydriasis.
Pharmacy pays
From ~$0.33· 6 formsFrequently asked
- What treats xerostomia?
- Our catalog lists 9 products that may treat xerostomia, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is brekiya (autoinjector).
- What is the best-rated treatment for xerostomia?
- By our independent recall-safety rating — not an efficacy measure — brekiya (autoinjector) ranks highest among the products we list for xerostomia. Always consult a professional.
- How are these treatments ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
- What types of drugs treat xerostomia?
- Treatments for xerostomia span FDA drug classes including ergotamine derivative, cholinergic receptor agonist. Compare every option side by side, ranked by independent rating, above.
Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.