Best treatments for substance withdrawal syndrome
3 products may treat substance withdrawal syndrome, spanning FDA drug classes such as typical antipsychotic, antihistamine. The current highest-rated option is haloperidol. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.
Quick answer: Of the 3 drugs we list for substance withdrawal syndrome, all are available as lower-cost generics, spanning classes such as typical antipsychotic, antihistamine. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for substance withdrawal syndrome — so confirm the right choice with your prescriber.
| # | Drug | Rating | Type | Form | Class | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|---|
| 1 | 68/100 | Prescription | Injectable | Typical Antipsychotic | Generic | $5 | View → | |
| 2 | Not yet rated | Prescription | Injectable | Antihistamine | Generic | $0 | View → | |
| 3 | Not yet rated | Prescription | Tablet | — | Generic | $288 | View → |
Full ranking · 3 treatments
haloperidol
Boxed warningPrescriptionFDA-sourced
Haloperidol is a typical antipsychotic used to treat Child Behavior Disorders, Tourette Syndrome, Psychotic Disorders, Schizophrenia.
Pharmacy pays
From ~$3.39/30· 6 formshydroxyzine hydrochloride
PrescriptionFDA-sourced
Hydroxyzine Hydrochloride is an antihistamine used to treat Anxiety Disorders, Nausea, Pruritus, Substance Withdrawal Syndrome.
Pharmacy pays
From ~$0.03· 5 formslucemyra
PrescriptionFDA-sourced
Lucemyra (Lofexidine Hydrochloride) is a medication used to treat Substance Withdrawal Syndrome.
Pharmacy pays
~$288.34 /30
Frequently asked
- What treats substance withdrawal syndrome?
- Our catalog lists 3 products that may treat substance withdrawal syndrome, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is haloperidol.
- What is the best-rated treatment for substance withdrawal syndrome?
- By our independent recall-safety rating — not an efficacy measure — haloperidol ranks highest among the products we list for substance withdrawal syndrome. Always consult a professional.
- How are these treatments ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
- What types of drugs treat substance withdrawal syndrome?
- Treatments for substance withdrawal syndrome span FDA drug classes including typical antipsychotic, antihistamine. Compare every option side by side, ranked by independent rating, above.
Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.