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Best treatments for acute myeloid leukemia

12 products may treat acute myeloid leukemia, spanning FDA drug classes such as anthracycline topoisomerase inhibitor, isocitrate dehydrogenase 2 inhibitor, hedgehog pathway inhibitor. The current highest-rated option is idarubicin hydrochloride. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.

Quick answer: Of the 12 drugs we list for acute myeloid leukemia, none are yet flagged as generics in our price data, spanning classes such as anthracycline topoisomerase inhibitor, isocitrate dehydrogenase 2 inhibitor, hedgehog pathway inhibitor. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for acute myeloid leukemia — so confirm the right choice with your prescriber.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Top-rated picks for acute myeloid leukemia: 1. Idarubicin Hydrochloride · 2. Idhifa · 3. Xospata

Top-rated treatments for acute myeloid leukemia, ranked by pharmaranks score
#DrugRatingPharmacy pays
172/100View →
272/100View →
372/100View →
470/100View →
568/100View →
664/100View →
764/100View →
8Not yet ratedView →
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Full ranking · 12 treatments

#1 of 5 in Anthracycline Topoisomerase Inhibitor

idarubicin hydrochloride

Boxed warning

PrescriptionFDA-sourced

72/100

Idarubicin Hydrochloride is an anthracycline topoisomerase inhibitor used to treat Breast Neoplasms, Bcr-Abl Positive Chronic Myelogenous Leukemia, Acute Myeloid Leukemia, Precursor Cell Lymphoblastic Leukemia-Lymphoma.

(10 data points)
anthracycline topoisomerase inhibitorbreast neoplasmsleukemia, myelogenous, chronic, bcr-abl positive

Price varies

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BRISTOL MYERS SQUIBB logo

idhifa

Boxed warning

PrescriptionFDA-sourced

72/100

Idhifa (Enasidenib Mesylate) is an isocitrate dehydrogenase 2 inhibitor used to treat Acute Myeloid Leukemia.

(4 data points)
isocitrate dehydrogenase 2 inhibitorleukemia, myeloid, acute

Price varies

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xospata

Boxed warning

PrescriptionFDA-sourced

72/100

Xospata (Gilteritinib Fumarate) is a medication used to treat Acute Myeloid Leukemia.

(4 data points)
leukemia, myeloid, acute

Price varies

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NOVARTIS logo

rydapt

PrescriptionFDA-sourced

70/100

Rydapt (Midostaurin) is a medication used to treat Acute Myeloid Leukemia, Hematologic Neoplasms, Systemic Mastocytosis.

(13 data points)
leukemia, myeloid, acutehematologic neoplasmsmastocytosis, systemic

Price varies

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#2 of 5 in Anthracycline Topoisomerase Inhibitor

daunorubicin hydrochloride

PrescriptionFDA-sourced

68/100

Daunorubicin Hydrochloride is an anthracycline topoisomerase inhibitor used to treat Acute Myeloid Leukemia, Precursor Cell Lymphoblastic Leukemia-Lymphoma.

(33 data points)
anthracycline topoisomerase inhibitorleukemia, myeloid, acuteprecursor cell lymphoblastic leukemia-lymphoma

Price varies

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PFIZER logo

daurismo

Boxed warning

PrescriptionFDA-sourced

64/100

Daurismo (Glasdegib Maleate) is a hedgehog pathway inhibitor used to treat Acute Myeloid Leukemia.

(61 data points)
hedgehog pathway inhibitorleukemia, myeloid, acute

Price varies

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Frequently asked

What treats acute myeloid leukemia?
Our catalog lists 12 products that may treat acute myeloid leukemia, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is idarubicin hydrochloride.
What is the best-rated treatment for acute myeloid leukemia?
By our independent recall-safety rating — not an efficacy measure — idarubicin hydrochloride ranks highest among the products we list for acute myeloid leukemia. Always consult a professional.
How are these treatments ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
What types of drugs treat acute myeloid leukemia?
Treatments for acute myeloid leukemia span FDA drug classes including anthracycline topoisomerase inhibitor, isocitrate dehydrogenase 2 inhibitor, hedgehog pathway inhibitor, cd33-directed immunoconjugate. Compare every option side by side, ranked by independent rating, above.

Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.