Best treatments for intractable pain
6 products may treat intractable pain, spanning FDA drug classes such as opioid agonist. The current highest-rated option is methadone hydrochloride. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.
Quick answer: Of the 6 drugs we list for intractable pain, all are available as lower-cost generics, spanning classes such as opioid agonist. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for intractable pain — so confirm the right choice with your prescriber.
Top-rated picks for intractable pain: 1. Methadone Hydrochloride · 2. Duramorph Pf · 3. Infumorph
| # | Drug | Rating | Type | Form | Class | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|---|
| 1 | 72/100 | Prescription | Injectable | Opioid Agonist | Generic | $0 | View → | |
| 2 | 70/100 | Prescription | Injectable | Opioid Agonist | Generic | $3 | View → | |
| 3 | 70/100 | Prescription | Injectable | Opioid Agonist | Generic | $3 | View → | |
| 4 | 70/100 | Prescription | Concentrate | Opioid Agonist | Generic | $0 | View → | |
| 5 | Not yet rated | Prescription | Tablet | Opioid Agonist | Generic | $3 | View → | |
| 6 | Not yet rated | Prescription | Tablet | Opioid Agonist | Generic | $3 | View → |
Narrow by drug class
Explore the class hubs: opioid agonist
Full ranking · 6 treatments
methadone hydrochloride
Boxed warningPrescriptionFDA-sourced
Methadone Hydrochloride is an opioid agonist used to treat Opioid-Related Disorders, Intractable Pain.
Pharmacy pays
From ~$0.06· 5 forms Save up to 70% in classduramorph pf
Boxed warningPrescriptionFDA-sourced
Duramorph Pf (Morphine Sulfate) is an opioid agonist used to treat Dyspnea, Intractable Pain.
Pharmacy pays
From ~$1.60· 7 forms Save up to 98% in classinfumorph
Boxed warningPrescriptionFDA-sourced
Infumorph (Morphine Sulfate) is an opioid agonist used to treat Dyspnea, Intractable Pain.
Pharmacy pays
From ~$1.60· 7 forms Save up to 98% in classmethadose
Boxed warningPrescriptionFDA-sourced
Methadose (Methadone Hydrochloride) is an opioid agonist used to treat Opioid-Related Disorders, Intractable Pain.
Pharmacy pays
From ~$0.06· 5 forms Save up to 70% in classmorphine sulfate
Boxed warningPrescriptionFDA-sourced
Morphine Sulfate is an opioid agonist used to treat Dyspnea, Intractable Pain.
Pharmacy pays
From ~$1.60· 7 forms Save up to 98% in classms contin
Boxed warningPrescriptionFDA-sourced
Ms Contin (Morphine Sulfate) is an opioid agonist used to treat Dyspnea, Intractable Pain.
Pharmacy pays
From ~$1.60· 7 forms Save up to 98% in classFrequently asked
- What treats intractable pain?
- Our catalog lists 6 products that may treat intractable pain, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is methadone hydrochloride.
- What is the best-rated treatment for intractable pain?
- By our independent recall-safety rating — not an efficacy measure — methadone hydrochloride ranks highest among the products we list for intractable pain. Always consult a professional.
- How are these treatments ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
- What types of drugs treat intractable pain?
- Treatments for intractable pain span FDA drug classes including opioid agonist. Compare every option side by side, ranked by independent rating, above.
Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.