Best treatments for orthostatic hypotension
10 products may treat orthostatic hypotension, spanning FDA drug classes such as ergotamine derivative, norepinephrine releasing agent, alpha-adrenergic agonist. The current highest-rated option is brekiya (autoinjector). Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.
Quick answer: Of the 10 drugs we list for orthostatic hypotension, 6 are available as lower-cost generics, spanning classes such as ergotamine derivative, norepinephrine releasing agent, alpha-adrenergic agonist. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for orthostatic hypotension — so confirm the right choice with your prescriber.
Top-rated picks for orthostatic hypotension: 1. Brekiya (Autoinjector) · 2. Ephedrine Sulfate · 3. Akovaz
| # | Drug | Rating | Type | Form | Class | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|---|
| 1 | 70/100 | Prescription | Injectable | Ergotamine Derivative | Generic | $35 | View → | |
| 2 | 68/100 | Prescription | Injectable | Norepinephrine Releasing Agent | No data | — | View → | |
| 3 | Not yet rated | Prescription | Injectable | Norepinephrine Releasing Agent | No data | — | View → | |
| 4 | Not yet rated | Prescription | Powder | Ergotamine Derivative | Generic | $35 | View → | |
| 5 | Not yet rated | Prescription | Injectable | Norepinephrine Releasing Agent | No data | — | View → | |
| 6 | Not yet rated | Prescription | Injectable | Ergotamine Derivative | Generic | $35 | View → | |
| 7 | Not yet rated | Prescription | Capsule | — | Generic | $49 | View → | |
| 8 | Not yet rated | Prescription | Injectable | Norepinephrine Releasing Agent | No data | — | View → | |
| 9 | Not yet rated | Prescription | Spray/Inhaler | Ergotamine Derivative | Generic | $35 | View → | |
| 10 | Not yet rated | Prescription | Spray/Inhaler | Ergotamine Derivative | Generic | $35 | View → |
Narrow by drug class
Explore the class hubs: ergotamine derivative · norepinephrine releasing agent
Full ranking · 10 treatments
brekiya (autoinjector)
Boxed warningPrescriptionFDA-sourced
Brekiya (Autoinjector) (Dihydroergotamine Mesylate) is an ergotamine derivative used to treat Cluster Headache, Postpartum Hemorrhage, Orthostatic Hypotension, Migraine Disorders.
Pharmacy pays
From ~$33.73· 2 formsephedrine sulfate
PrescriptionFDA-sourced
Ephedrine Sulfate is a norepinephrine releasing agent used to treat Asthma, Bronchial Spasm, Orthostatic Hypotension, Rhinitis.
Price varies
akovaz
PrescriptionFDA-sourced
Akovaz (Ephedrine Sulfate) is a norepinephrine releasing agent used to treat Asthma, Bronchial Spasm, Orthostatic Hypotension, Rhinitis.
Price varies
atzumi
Boxed warningPrescriptionFDA-sourced
Atzumi (Dihydroergotamine Mesylate) is an ergotamine derivative used to treat Cluster Headache, Postpartum Hemorrhage, Orthostatic Hypotension, Migraine Disorders.
Pharmacy pays
From ~$33.73· 2 formscorphedra
PrescriptionFDA-sourced
Corphedra (Ephedrine Sulfate) is a norepinephrine releasing agent used to treat Asthma, Bronchial Spasm, Orthostatic Hypotension, Rhinitis.
Price varies
dihydroergotamine mesylate
Boxed warningPrescriptionFDA-sourced
Dihydroergotamine Mesylate is an ergotamine derivative used to treat Cluster Headache, Postpartum Hemorrhage, Orthostatic Hypotension, Migraine Disorders.
Pharmacy pays
From ~$33.73· 2 formsFrequently asked
- What treats orthostatic hypotension?
- Our catalog lists 10 products that may treat orthostatic hypotension, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is brekiya (autoinjector).
- What is the best-rated treatment for orthostatic hypotension?
- By our independent recall-safety rating — not an efficacy measure — brekiya (autoinjector) ranks highest among the products we list for orthostatic hypotension. Always consult a professional.
- How are these treatments ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
- What types of drugs treat orthostatic hypotension?
- Treatments for orthostatic hypotension span FDA drug classes including ergotamine derivative, norepinephrine releasing agent, alpha-adrenergic agonist, beta-adrenergic agonist. Compare every option side by side, ranked by independent rating, above.
Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.