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Best treatments for huntington disease

5 products may treat huntington disease, spanning FDA drug classes such as phenothiazine, gamma-aminobutyric acid-ergic agonist, vesicular monoamine transporter 2 inhibitor. The current highest-rated option is perphenazine. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.

Quick answer: Of the 5 drugs we list for huntington disease, all are available as lower-cost generics, spanning classes such as phenothiazine, gamma-aminobutyric acid-ergic agonist, vesicular monoamine transporter 2 inhibitor. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for huntington disease — so confirm the right choice with your prescriber.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate
Treatments we list for huntington disease
#DrugRatingPharmacy pays
168/100$6View →
2Not yet rated$2View →
3Not yet rated$2View →
4Not yet rated$2View →
5Not yet rated$30View →

Full ranking · 5 treatments

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perphenazine

Boxed warning

PrescriptionFDA-sourced

68/100

Perphenazine is a phenothiazine used to treat Tourette Syndrome, Huntington Disease, Nausea, Psychotic Disorders.

(23 data points)
phenothiazinetourette syndromehuntington disease

Pharmacy pays

From ~$4.95/30· 4 forms Save up to 73% in class
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gablofen

Boxed warning

PrescriptionFDA-sourced

New

Gablofen (Baclofen) is a gamma-aminobutyric acid-ergic agonist used to treat Neurogenic Urinary Bladder, Cerebral Palsy, Hiccup, Huntington Disease.

gamma-aminobutyric acid-ergic agonisturinary bladder, neurogeniccerebral palsy

Pharmacy pays

From ~$1.00/30· 7 forms
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ozobax

PrescriptionFDA-sourced

New

Ozobax (Baclofen) is a gamma-aminobutyric acid-ergic agonist used to treat Neurogenic Urinary Bladder, Cerebral Palsy, Hiccup, Huntington Disease.

gamma-aminobutyric acid-ergic agonisturinary bladder, neurogeniccerebral palsy

Pharmacy pays

From ~$1.00/30· 7 forms
View details →

ozobax ds

PrescriptionFDA-sourced

New

Ozobax Ds (Baclofen) is a gamma-aminobutyric acid-ergic agonist used to treat Neurogenic Urinary Bladder, Cerebral Palsy, Hiccup, Huntington Disease.

gamma-aminobutyric acid-ergic agonisturinary bladder, neurogeniccerebral palsy

Pharmacy pays

From ~$1.00/30· 7 forms
View details →

xenazine

Boxed warning

PrescriptionFDA-sourced

New

Xenazine (Tetrabenazine) is a vesicular monoamine transporter 2 inhibitor used to treat Huntington Disease, Hyperkinesis.

vesicular monoamine transporter 2 inhibitorhuntington diseasehyperkinesis

Pharmacy pays

From ~$23.86/30· 2 forms
View details →

Frequently asked

What treats huntington disease?
Our catalog lists 5 products that may treat huntington disease, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is perphenazine.
What is the best-rated treatment for huntington disease?
By our independent recall-safety rating — not an efficacy measure — perphenazine ranks highest among the products we list for huntington disease. Always consult a professional.
How are these treatments ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
What types of drugs treat huntington disease?
Treatments for huntington disease span FDA drug classes including phenothiazine, gamma-aminobutyric acid-ergic agonist, vesicular monoamine transporter 2 inhibitor. Compare every option side by side, ranked by independent rating, above.

Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.