Best treatments for fissure in ano
12 products may treat fissure in ano, spanning FDA drug classes such as alpha-1 adrenergic agonist, nitrate vasodilator. The current highest-rated option is botox. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.
Quick answer: Of the 12 drugs we list for fissure in ano, 9 are available as lower-cost generics, spanning classes such as alpha-1 adrenergic agonist, nitrate vasodilator. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for fissure in ano — so confirm the right choice with your prescriber.
Top-rated picks for fissure in ano: 1. Botox · 2. Botox Cosmetic · 3. Immphentiv
| # | Drug | Rating | Type | Form | Class | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|---|
| 1 | 72/100 | Prescription | Injectable | — | No data | — | View → | |
| 2 | 72/100 | Prescription | Injectable | — | No data | — | View → | |
| 3 | 72/100 | Prescription | Injectable | alpha-1 Adrenergic Agonist | Generic | $9 | View → | |
| 4 | 70/100 | Prescription | Tablet | Nitrate Vasodilator | Generic | $4 | View → | |
| 5 | Not yet rated | Prescription | Injectable | alpha-1 Adrenergic Agonist | Generic | $9 | View → | |
| 6 | Not yet rated | Prescription | Injectable | — | No data | — | View → | |
| 7 | Not yet rated | Prescription | Patch | Nitrate Vasodilator | Generic | $4 | View → | |
| 8 | Not yet rated | Prescription | Injectable | Nitrate Vasodilator | Generic | $4 | View → | |
| 9 | Not yet rated | Prescription | Spray/Inhaler | Nitrate Vasodilator | Generic | $4 | View → | |
| 10 | Not yet rated | Prescription | Spray/Inhaler | Nitrate Vasodilator | Generic | $4 | View → |
Narrow by drug class
Explore the class hubs: nitrate vasodilator · alpha-1 adrenergic agonist
Full ranking · 12 treatments
botox
Boxed warningPrescriptionFDA-sourced
Botox (Onabotulinumtoxina) is a medication used to treat Blepharospasm, Dystonia, Fissure in Ano, Muscle Rigidity.
Price varies
botox cosmetic
Boxed warningPrescriptionFDA-sourced
Botox Cosmetic (Onabotulinumtoxina) is a medication used to treat Blepharospasm, Dystonia, Fissure in Ano, Muscle Rigidity.
Price varies
immphentiv
PrescriptionFDA-sourced
Immphentiv (Phenylephrine Hydrochloride) is an alpha-1 adrenergic agonist used to treat Fissure in Ano, Open-Angle Glaucoma, Hemorrhoids, Hypotension.
Pharmacy pays
From ~$5.30· 2 forms
nitrostat
PrescriptionFDA-sourced
Nitrostat (Nitroglycerin) is a nitrate vasodilator used to treat Angina Pectoris, Eclampsia, Fissure in Ano, Heart Failure.
Pharmacy pays
From ~$2.19/30· 8 formsbiorphen
PrescriptionFDA-sourced
Biorphen (Phenylephrine Hydrochloride) is an alpha-1 adrenergic agonist used to treat Fissure in Ano, Open-Angle Glaucoma, Hemorrhoids, Hypotension.
Pharmacy pays
From ~$5.30· 2 formsletybo
Boxed warningPrescriptionFDA-sourced
Letybo (Letibotulinumtoxina-Wlbg) is a medication used to treat Blepharospasm, Dystonia, Fissure in Ano, Muscle Rigidity.
Price varies
Frequently asked
- What treats fissure in ano?
- Our catalog lists 12 products that may treat fissure in ano, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is botox.
- What is the best-rated treatment for fissure in ano?
- By our independent recall-safety rating — not an efficacy measure — botox ranks highest among the products we list for fissure in ano. Always consult a professional.
- How are these treatments ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
- What types of drugs treat fissure in ano?
- Treatments for fissure in ano span FDA drug classes including alpha-1 adrenergic agonist, nitrate vasodilator. Compare every option side by side, ranked by independent rating, above.
Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.