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Best treatments for burns

14 products may treat burns, spanning FDA drug classes such as general anesthetic, amide local anesthetic, antiarrhythmic. The current highest-rated option is ketamine hydrochloride. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.

Quick answer: Of the 14 drugs we list for burns, 10 are available as lower-cost generics, spanning classes such as general anesthetic, amide local anesthetic, antiarrhythmic. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for burns — so confirm the right choice with your prescriber.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Understanding burns

"Burns" is broader than fire. MedlinePlus (NLM) defines a burn as "damage to your body's tissues caused by heat, chemicals, electricity, sunlight, or radiation" — so scalds, sunburn, chemical splashes and electrical injury all sit in one category, and MedlinePlus names scalds from hot liquids and steam, building fires, and flammable liquids and gases as the most common causes. Depth is what classifies a burn, and pain is a misleading guide to it. StatPearls (NCBI Bookshelf, "Burn Classification") describes a superficial first-degree burn as involving "the epidermis only," pink-to-red, dry, without blistering, and "moderately painful"; a superficial partial-thickness (second-degree) burn as reaching the superficial dermis, blistered, with a wound bed that "will blanch with pressure," and painful. But a deep partial-thickness burn, reaching the deeper reticular dermis, blanches only sluggishly and — StatPearls states — leaves the patient with "minimal pain," and a full-thickness (third-degree) burn extends into the subcutaneous tissue, looks "leathery, stiff, and dry," "does not blanch under pressure," and leaves "no sensation or pain." The thing people get backwards: a burn that has stopped hurting is usually the deeper, more dangerous one. That classification then decides what gets counted. StatPearls ("Rule of Nines") states that "only second- and third-degree burns, more commonly referred to as partial- and full-thickness burns, respectively, are included in the determination of the TBSA," and the Burn Classification chapter puts it flatly: "Superficial burns are not included in the calculation of TBSA." So an extensive sunburn adds nothing to the burn total. For the burn that does count, StatPearls describes measuring the affected area against "the patient's palm with fingers adducted, which is advertised to be 1% TBSA." This is general information, not medical advice.

First-line treatment

Triage, not a prescription, drives burn care. The American Burn Association's Guidelines for Burn Patient Referral list, under "Immediate Consultation with Consideration for Transfer": "Full thickness burns"; "Partial thickness ≥10% TBSA"; "Any deep partial or full thickness burns involving the face, hands, genitalia, feet, perineum, or over any joints"; "All chemical injuries"; "All high voltage (≥1,000V) electrical injuries"; "Lightning injury"; and "All patients with suspected inhalation injury." Two entries people miss: the ABA also lists "All potentially deep burns of any size," and says "All pediatric burns may benefit from burn center referral" — a small burn is not automatically a minor one. For minor burns, MedlinePlus (NLM) is explicit about first aid: "Run cool water over the area of the burn or soak it in a cool water bath (not ice water). Keep the area under water for at least 5 to 30 minutes," and "Do not apply oil, butter, ice, medicines, cream, oil spray, or any household remedy to a severe burn." Drug choice and any fluid resuscitation are decided by clinicians.

Top-rated picks for burns: 1. Ketamine Hydrochloride · 2. Lidocaine Hydrochloride Preservative Free · 3. Akten

Top-rated treatments for burns, ranked by pharmaranks score
#DrugRatingPharmacy pays
172/100$1View →
272/100$0View →
370/100$0View →
4Not yet ratedView →
5Not yet rated$0View →
6Not yet rated$0View →
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8Not yet rated$1View →
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10Not yet rated$0View →

Full ranking · 14 treatments

#1 of 3 in General Anesthetic

ketamine hydrochloride

PrescriptionFDA-sourced

72/100

Ketamine Hydrochloride is a general anesthetic used to treat Burns, Pain.

(10 data points)
general anestheticburnspain

Pharmacy pays

From ~$0.53· 2 forms Save up to 83% in class
View details →
#1 of 15 in Amide Local Anesthetic

lidocaine hydrochloride preservative free

PrescriptionFDA-sourced

72/100

Lidocaine Hydrochloride Preservative Free (Lidocaine Hydrochloride) is an amide local anesthetic used to treat Burns, Esophageal Diseases, Mouth Diseases, Myocardial Infarction.

(10 data points)
amide local anestheticantiarrhythmicburns

Pharmacy pays

From ~$0.07· 8 forms Save up to 74% in class
View details →
THEA PHARMA logo
#2 of 15 in Amide Local Anesthetic

akten

PrescriptionFDA-sourced

70/100

Akten (Lidocaine Hydrochloride) is an amide local anesthetic used to treat Burns, Esophageal Diseases, Mouth Diseases, Myocardial Infarction.

(2 data points)
amide local anestheticantiarrhythmicburns

Pharmacy pays

From ~$0.07· 8 forms Save up to 74% in class
View details →
INSMED INC logo

arikayce kit

Boxed warning

PrescriptionFDA-sourced

New

Arikayce Kit (Amikacin Sulfate) is an aminoglycoside antibacterial used to treat Acinetobacter Infections, Infectious Bone Diseases, Burns, Central Nervous System Infections.

aminoglycoside antibacterialacinetobacter infectionsbone diseases, infectious

Price varies

View details →
ALCON logo

betadine

PrescriptionFDA-sourced

New

Betadine (Povidone-Iodine) is a medication used to treat Burns, Leg Ulcer, Radiation Injuries, Staphylococcal Infections.

burnsleg ulcerradiation injuries

Pharmacy pays

$0.02 /mL

View details →

bondlido

PrescriptionFDA-sourced

New

Bondlido (Lidocaine) is an amide local anesthetic used to treat Burns, Esophageal Diseases, Mouth Diseases, Pain.

amide local anestheticantiarrhythmicburns

Pharmacy pays

From ~$0.07· 8 forms Save up to 74% in class
View details →

Frequently asked

What treats burns?
Our catalog lists 14 products that may treat burns, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is ketamine hydrochloride.
What is the best-rated treatment for burns?
By our independent recall-safety rating — not an efficacy measure — ketamine hydrochloride ranks highest among the products we list for burns. Always consult a professional.
How are these treatments ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
What types of drugs treat burns?
Treatments for burns span FDA drug classes including general anesthetic, amide local anesthetic, antiarrhythmic, aminoglycoside antibacterial, blood coagulation factor. Compare every option side by side, ranked by independent rating, above.

Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.

Sources

The clinical overview above is written from these authoritative public-health and medical-society sources, independently reviewed against each.