DOXEPIN HYDROCHLORIDE vs ZONALON

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Attribute	DOXEPIN HYDROCHLORIDE	ZONALON
Rating	70/100	66/100
Pharmacy pays	~$4.84 /30	~$4.84 /30
Type	RX	RX
Active ingredient	DOXEPIN HYDROCHLORIDE	DOXEPIN HYDROCHLORIDE
Manufacturer	Watson Labs	Mylan
Dosage forms	Capsule, Topical, Solution, Tablet	Topical
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	None	None
Half-life	about 8 to 24 hours (average about 17 hours)	about 8 to 24 hours (average about 17 hours)
Treats	Anxiety Disorders, Depressive Disorder, Atopic Dermatitis	Anxiety Disorders, Depressive Disorder, Atopic Dermatitis

doxepin hydrochloride zonalon

Rating

70/100

66/100

Pharmacy pays

~$4.84 /30

Type

Active ingredient

DOXEPIN HYDROCHLORIDE

Manufacturer

Watson Labs

Mylan

Dosage forms

Capsule, Topical, Solution, Tablet

Topical

Drug class

Tricyclic Antidepressant

Boxed warning

None

Half-life

about 8 to 24 hours (average about 17 hours)

Treats

Anxiety Disorders, Depressive Disorder, Atopic Dermatitis

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Frequently asked questions

Which is better-rated, Doxepin Hydrochloride or Zonalon?

By our independent rating, Doxepin Hydrochloride scores higher — 3.5 vs 3.3 out of 5 for Zonalon. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Doxepin Hydrochloride or Zonalon?

Pharmacies pay about the same to acquire either one — roughly $4.84 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Doxepin Hydrochloride and Zonalon?

Both Doxepin Hydrochloride and Zonalon share the active ingredient Doxepin Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.