ZOFRAN vs ZOFRAN ODT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. ZOFRAN and ZOFRAN ODT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ZOFRAN	ZOFRAN ODT
Rating	68/100	68/100
Pharmacy pays	$0.15 /mL	$0.15 /mL
Type	RX	RX
Active ingredient	ONDANSETRON HYDROCHLORIDE	ONDANSETRON
Manufacturer	Sandoz	Sandoz
Dosage forms	Tablet	Tablet, orally disintegrating
Drug class	Serotonin-3 Receptor Antagonist	Serotonin-3 Receptor Antagonist
Boxed warning	None	None
Half-life	about 3 to 5 hours (roughly 4 hours) in healthy adults	about 3 to 5 hours (roughly 4 hours) in healthy adults
Treats	Alcoholism	Alcoholism

zofran zofran odt

Rating

68/100

Pharmacy pays

$0.15 /mL

Type

Active ingredient

ONDANSETRON HYDROCHLORIDE

ONDANSETRON

Manufacturer

Sandoz

Dosage forms

Tablet

Tablet, orally disintegrating

Drug class

Serotonin-3 Receptor Antagonist

Boxed warning

None

Half-life

about 3 to 5 hours (roughly 4 hours) in healthy adults

Treats

Alcoholism

Frequently asked questions

Which is better-rated, Zofran or Zofran ODT?

Zofran and Zofran ODT are tied at 3.4 out of 5 by our independent rating.

Which is cheaper, Zofran or Zofran ODT?

Pharmacies pay about the same to acquire either one — roughly $0.15 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Zofran and Zofran ODT?

Zofran contains Ondansetron Hydrochloride, while Zofran ODT contains Ondansetron — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.