ONDANSETRON HYDROCHLORIDE vs ZOFRAN PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Attribute	ONDANSETRON HYDROCHLORIDE	ZOFRAN PRESERVATIVE FREE
Rating	70/100	68/100
Pharmacy pays	$0.15 /mL	$0.15 /mL
Type	RX	RX
Active ingredient	ONDANSETRON HYDROCHLORIDE	ONDANSETRON HYDROCHLORIDE
Manufacturer	Lannett Co Inc	Sandoz
Dosage forms	Solution	Injectable
Drug class	Serotonin-3 Receptor Antagonist	Serotonin-3 Receptor Antagonist
Boxed warning	None	None
Half-life	about 3 to 5 hours (roughly 4 hours) in healthy adults	about 3 to 5 hours (roughly 4 hours) in healthy adults
Treats	Alcoholism	Alcoholism

ondansetron hydrochloride zofran preservative free

Rating

70/100

68/100

Pharmacy pays

$0.15 /mL

Type

Active ingredient

ONDANSETRON HYDROCHLORIDE

Manufacturer

Lannett Co Inc

Sandoz

Dosage forms

Solution

Injectable

Drug class

Serotonin-3 Receptor Antagonist

Boxed warning

None

Half-life

about 3 to 5 hours (roughly 4 hours) in healthy adults

Treats

Alcoholism

Frequently asked questions

Which is better-rated, Ondansetron Hydrochloride or Zofran Preservative Free?

By our independent rating, Ondansetron Hydrochloride scores higher — 3.5 vs 3.4 out of 5 for Zofran Preservative Free. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Ondansetron Hydrochloride or Zofran Preservative Free?

Pharmacies pay about the same to acquire either one — roughly $0.15 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Ondansetron Hydrochloride and Zofran Preservative Free?

Both Ondansetron Hydrochloride and Zofran Preservative Free share the active ingredient Ondansetron Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.