ONDANSETRON vs ZOFRAN ODT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Attribute	ONDANSETRON	ZOFRAN ODT
Rating	56/100	68/100
Pharmacy pays	$0.15 /mL	$0.15 /mL
Type	RX	RX
Active ingredient	ONDANSETRON	ONDANSETRON
Manufacturer	Teva	Sandoz
Dosage forms	Injectable, Solution, Tablet, Tablet, orally disintegrating	Tablet, orally disintegrating
Drug class	Serotonin-3 Receptor Antagonist	Serotonin-3 Receptor Antagonist
Boxed warning	None	None
Half-life	about 3 to 5 hours (roughly 4 hours) in healthy adults	about 3 to 5 hours (roughly 4 hours) in healthy adults
Treats	Alcoholism	Alcoholism

ondansetron zofran odt

Rating

56/100

68/100

Pharmacy pays

$0.15 /mL

Type

Active ingredient

ONDANSETRON

Manufacturer

Teva

Sandoz

Dosage forms

Injectable, Solution, Tablet, Tablet, orally disintegrating

Tablet, orally disintegrating

Drug class

Serotonin-3 Receptor Antagonist

Boxed warning

None

Half-life

about 3 to 5 hours (roughly 4 hours) in healthy adults

Treats

Alcoholism

Frequently asked questions

Which is better-rated, Ondansetron or Zofran ODT?

By our independent rating, Zofran ODT scores higher — 3.4 vs 2.8 out of 5 for Ondansetron. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Ondansetron or Zofran ODT?

Pharmacies pay about the same to acquire either one — roughly $0.15 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Ondansetron and Zofran ODT?

Both Ondansetron and Zofran ODT share the active ingredient Ondansetron.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.