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XYZAL ALLERGY 24HR vs ZYRTEC ALLERGY

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 15, 2026·How we rate

Rating

New
70/100

Pharmacy pays

$0.06 /mL
$0.06 /mL

Type

OTC
OTC

Active ingredient

LEVOCETIRIZINE DIHYDROCHLORIDE
CETIRIZINE HYDROCHLORIDE

Dosage forms

Tablet
Capsule, Tablet, Tablet, orally disintegrating, Kit

Drug class

Histamine-1 Receptor Antagonist
Histamine-1 Receptor Antagonist

Boxed warning

None
None

Half-life

about 8.3 hours (mean in healthy adults)

Treats

Seasonal Allergic Rhinitis, Perennial Allergic Rhinitis, Urticaria
Perennial Allergic Rhinitis, Urticaria

Get zyrtec allergyhigher-rated option

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Get treatment online

Licensed online providers — consult & get prescribed if eligible.

Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

Which is cheaper, Xyzal Allergy 24hr or Zyrtec Allergy?

Xyzal Allergy 24hr costs pharmacies less to acquire — about $0.06 vs $0.06 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Xyzal Allergy 24hr and Zyrtec Allergy?

Xyzal Allergy 24hr contains Levocetirizine Dihydrochloride, while Zyrtec Allergy contains Cetirizine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.