XYLOCAINE vs XYLOCAINE PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Attribute	XYLOCAINE	XYLOCAINE PRESERVATIVE FREE
Rating	70/100	68/100
Pharmacy pays	$0.24 /mL	$0.24 /mL
Type	RX	RX
Active ingredient	LIDOCAINE HYDROCHLORIDE	LIDOCAINE HYDROCHLORIDE
Manufacturer	Epic Pharma LLC	Fresenius Kabi USA
Dosage forms	Injectable	Injectable
Drug class	Amide Local Anesthetic	Amide Local Anesthetic
Boxed warning	None	None
Treats	Burns, Esophageal Diseases, Mouth Diseases	Burns, Esophageal Diseases, Mouth Diseases

xylocaine xylocaine preservative free

Rating

70/100

68/100

Pharmacy pays

$0.24 /mL

Type

Active ingredient

LIDOCAINE HYDROCHLORIDE

Manufacturer

Epic Pharma LLC

Fresenius Kabi USA

Dosage forms

Injectable

Drug class

Amide Local Anesthetic

Boxed warning

None

Treats

Burns, Esophageal Diseases, Mouth Diseases

Frequently asked questions

Which is better-rated, Xylocaine or Xylocaine Preservative Free?

By our independent rating, Xylocaine scores higher — 3.5 vs 3.4 out of 5 for Xylocaine Preservative Free. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Xylocaine or Xylocaine Preservative Free?

Pharmacies pay about the same to acquire either one — roughly $0.24 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Xylocaine and Xylocaine Preservative Free?

Both Xylocaine and Xylocaine Preservative Free share the active ingredient Lidocaine Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.