WELLBUTRIN XL vs ZYBAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Attribute	WELLBUTRIN XL	ZYBAN
Rating	New	70/100
Pharmacy pays	~$2.52 /30	~$2.52 /30
Type	RX	RX
Active ingredient	BUPROPION HYDROCHLORIDE	BUPROPION HYDROCHLORIDE
Manufacturer	Bausch	Glaxosmithkline
Dosage forms	Tablet, extended release	Tablet, extended release
Drug class	Aminoketone	Aminoketone
Boxed warning	Boxed warning	None
Half-life	about 21 hours on average (±9 hours)	about 21 hours on average (±9 hours)
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder

wellbutrin xl zyban

Rating

New

70/100

Pharmacy pays

~$2.52 /30

Type

Active ingredient

BUPROPION HYDROCHLORIDE

Manufacturer

Bausch

Glaxosmithkline

Dosage forms

Tablet, extended release

Drug class

Aminoketone

Boxed warning

None

Half-life

about 21 hours on average (±9 hours)

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Tobacco Use Disorder

Get zybanhigher-rated option

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Frequently asked questions

Which is cheaper, Wellbutrin XL or Zyban?

Pharmacies pay about the same to acquire either one — roughly $2.52 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Wellbutrin XL and Zyban?

Both Wellbutrin XL and Zyban share the active ingredient Bupropion Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.